Enteroantigen-presenting B cells efficiently stimulate CD4(+) T cells in vitro
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Presentation of enterobacterial antigens by antigen-presenting cells and activation of enteroantigen-specific CD4(+) T cells are considered crucial steps in inflammatory bowel disease (IBD) pathology. The detrimental effects of such CD4(+) T cells have been thoroughly demonstrated in models of colitis. Also, we have previously established an in vitro assay where murine enteroantigen-specific colitogenic CD4(+) CD25(-) T cells are activated by splenocytes pulsed with an enterobacterial extract.
Originalsprog | Engelsk |
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Tidsskrift | Inflammatory Bowel Diseases |
Vol/bind | 17 |
Udgave nummer | 1 |
Sider (fra-til) | 308-18 |
Antal sider | 11 |
ISSN | 1078-0998 |
DOI | |
Status | Udgivet - 2011 |
ID: 32242512