TY - JOUR

T1 - Elevated Levels of Interleukin-1β and Interleukin-10 Are Associated With Faster Lung Function Decline in People With Well-Treated Human Immunodeficiency Virus

AU - Thudium, Rebekka F

AU - Arentoft, Nicoline S

AU - Hoel, Hedda

AU - Afzal, Shoaib

AU - Von Stemann, Jakob H

AU - Forman, Julie L

AU - Wilcke, Jon T

AU - Benfield, Thomas

AU - Trøseid, Marius

AU - Borges, Álvaro H

AU - Ostrowski, Sisse R

AU - Vestbo, Jørgen

AU - Kunisaki, Ken M

AU - Jensen, Jens-ulrik S

AU - Nielsen, Susanne D

PY - 2023

Y1 - 2023

N2 - BackgroundPeople with human immunodeficiency virus (PWH) have an increased risk of chronic lung diseases and chronic inflammation. We aimed to investigate if inflammatory markers and monocyte activation are associated with faster lung function decline in PWH.MethodsWe included 655 PWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study. Eligible participants were aged ≥25 years and had 2 spirometries separated by >2 years. Inflammatory markers (interleukin [IL]–1β, IL-2, IL-6, IL-10, tumor necrosis factor–α, and interferon-γ) were measured at baseline by Luminex, and soluble CD14 and soluble CD163 by enzyme-linked immunosorbent assay. Using linear mixed models, we investigated whether elevated cytokine levels were associated with faster lung function decline.ResultsThe majority of PWH were males (85.2%) with undetectable viral replication (95.3%). We found a faster decline in forced expiratory volume in 1 second (FEV1) in PWH with elevated IL-1β and IL-10, with an additional decline of 10.3 mL/year (95% confidence interval [CI], 2.1–18.6; P = .014) and 10.0 mL/year (95% CI, 1.8–18.2; P = .017), respectively. We found no interaction between smoking and IL-1β or IL-10 on FEV1 decline.ConclusionsElevated IL-1β and IL-10 were independently associated with faster lung function decline in PWH, suggesting that dysregulated systemic inflammation may play a role in the pathogenesis of chronic lung diseases.

AB - BackgroundPeople with human immunodeficiency virus (PWH) have an increased risk of chronic lung diseases and chronic inflammation. We aimed to investigate if inflammatory markers and monocyte activation are associated with faster lung function decline in PWH.MethodsWe included 655 PWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study. Eligible participants were aged ≥25 years and had 2 spirometries separated by >2 years. Inflammatory markers (interleukin [IL]–1β, IL-2, IL-6, IL-10, tumor necrosis factor–α, and interferon-γ) were measured at baseline by Luminex, and soluble CD14 and soluble CD163 by enzyme-linked immunosorbent assay. Using linear mixed models, we investigated whether elevated cytokine levels were associated with faster lung function decline.ResultsThe majority of PWH were males (85.2%) with undetectable viral replication (95.3%). We found a faster decline in forced expiratory volume in 1 second (FEV1) in PWH with elevated IL-1β and IL-10, with an additional decline of 10.3 mL/year (95% confidence interval [CI], 2.1–18.6; P = .014) and 10.0 mL/year (95% CI, 1.8–18.2; P = .017), respectively. We found no interaction between smoking and IL-1β or IL-10 on FEV1 decline.ConclusionsElevated IL-1β and IL-10 were independently associated with faster lung function decline in PWH, suggesting that dysregulated systemic inflammation may play a role in the pathogenesis of chronic lung diseases.

U2 - 10.1093/infdis/jiad233

DO - 10.1093/infdis/jiad233

M3 - Journal article

C2 - 37366576

VL - 228

SP - 1080

EP - 1088

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 8

ER -