TY - JOUR

T1 - Electrokinetic migration of acidic drugs across a supported liquid membrane

AU - Balchen, Marte

AU - Gjelstad, Astrid

AU - Rasmussen, Knut Einar

AU - Pedersen-Bjergaard, Stig

PY - 2007/6/8

Y1 - 2007/6/8

N2 - Electrokinetic cross membrane extraction of acidic drugs was demonstrated for the first time. The acidic drugs were extracted from an alkaline aqueous donor solution (300 μl), through a thin supported liquid membrane of 1-heptanol sustained in the pores of the wall of a porous hollow fiber, and into an aqueous alkaline acceptor solution (30 μl) present inside the lumen of the hollow fiber by the application of a d.c. electrical potential. The negative electrode was placed in the donor solution, and the positive electrode was placed in the acceptor solution. Optimal extractions were accomplished with 1-heptanol as the supported liquid membrane, with 50 V as the driving force, and with pH 12.0 in both the donor and acceptor solutions, respectively (NaOH). Equilibrium extraction conditions were obtained after 5 min of operation with the whole assembly agitated at 1200 rpm. Eleven different acidic drugs were extracted with recovery values between 8 and 100%, and initial data supported that electrokinetic cross membrane extraction provided repeatable data and linear response between original donor concentration and final acceptor concentration of the acidic model compounds.

AB - Electrokinetic cross membrane extraction of acidic drugs was demonstrated for the first time. The acidic drugs were extracted from an alkaline aqueous donor solution (300 μl), through a thin supported liquid membrane of 1-heptanol sustained in the pores of the wall of a porous hollow fiber, and into an aqueous alkaline acceptor solution (30 μl) present inside the lumen of the hollow fiber by the application of a d.c. electrical potential. The negative electrode was placed in the donor solution, and the positive electrode was placed in the acceptor solution. Optimal extractions were accomplished with 1-heptanol as the supported liquid membrane, with 50 V as the driving force, and with pH 12.0 in both the donor and acceptor solutions, respectively (NaOH). Equilibrium extraction conditions were obtained after 5 min of operation with the whole assembly agitated at 1200 rpm. Eleven different acidic drugs were extracted with recovery values between 8 and 100%, and initial data supported that electrokinetic cross membrane extraction provided repeatable data and linear response between original donor concentration and final acceptor concentration of the acidic model compounds.

KW - Acidic drugs

KW - Electrokinetic migration

KW - Sample preparation

KW - Supported liquid membranes

UR - http://www.scopus.com/inward/record.url?scp=34248598187&partnerID=8YFLogxK

U2 - 10.1016/j.chroma.2006.10.096

DO - 10.1016/j.chroma.2006.10.096

M3 - Journal article

C2 - 17126351

AN - SCOPUS:34248598187

VL - 1152

SP - 220

EP - 225

JO - Journal of Chromatography

JF - Journal of Chromatography

SN - 0301-4770

IS - 1-2

ER -