Electrocardiographic characteristics of newborns with ventricular septal defects: a Copenhagen Baby Heart Study
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Ventricular septal defects (VSD) represent the most common congenital heart defect in newborns. We assessed the electrocardiographic characteristics of newborns with VSDs in a general population sample. The Copenhagen Baby Heart Study is a prospective population–based cohort study offering cardiac evaluation of newborns. Echocardiograms and electrocardiograms were obtained within 30 days after birth and systematically analysed. A VSD was identified in 530 newborns (mean age 11 ± 7 days, 42% boys). Newborns with VSDs had a more left-shifted QRS axis (116 ± 34 vs. 120 ± 3°, p = 0.02), and a higher S-wave amplitude in V1 (721 ± 584 vs. 636 ± 549 µV, p = 0.001) than controls. The largest differences were found in newborns with large or perimembraneous VSDs with a higher frequency of left axis deviation, higher S-wave amplitudes in V1, and higher R- and S-wave amplitudes in V6 compared with controls. R-waves in V1 and V6 were significantly associated to left ventricular mass, whereas S-waves in V1 and V6 were dependent on left ventricular end-diastolic diameter on echocardiography.
Conclusion: Newborns with VSDs showed significant differences in QRS axis, and R- and S-wave precordial amplitudes compared to matched controls. Perimembranous and large VSDs had the greatest effect on the neonatal ECG.
Conclusion: Newborns with VSDs showed significant differences in QRS axis, and R- and S-wave precordial amplitudes compared to matched controls. Perimembranous and large VSDs had the greatest effect on the neonatal ECG.
Originalsprog | Engelsk |
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Tidsskrift | European Journal of Pediatrics |
Vol/bind | 182 |
Udgave nummer | 11 |
Sider (fra-til) | 5149-5158 |
Antal sider | 10 |
ISSN | 0340-6199 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
Open access funding provided by Royal Library, Copenhagen University Library. This study was supported by the Danish Heart Association, the Danish Children Heart Foundation, Candy’s Foundation, the Toyota Foundation, and the Herlev-Gentofte Hospital Research Foundation.
Publisher Copyright:
© 2023, The Author(s).
ID: 375052692