Effects of tofacitinib on cardiovascular risk factors and cardiovascular outcomes based on phase III and long-term extension data in patients with plaque psoriasis
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Effects of tofacitinib on cardiovascular risk factors and cardiovascular outcomes based on phase III and long-term extension data in patients with plaque psoriasis. / Wu, Jashin J; Strober, Bruce E; Hansen, Peter R; Ahlehoff, Ole; Egeberg, Alexander; Qureshi, Abrar A; Robertson, Debbie; Valdez, Hernan; Tan, Huaming; Wolk, Robert.
I: Journal of the American Academy of Dermatology, Bind 75, Nr. 5, 11.2016, s. 897-905.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effects of tofacitinib on cardiovascular risk factors and cardiovascular outcomes based on phase III and long-term extension data in patients with plaque psoriasis
AU - Wu, Jashin J
AU - Strober, Bruce E
AU - Hansen, Peter R
AU - Ahlehoff, Ole
AU - Egeberg, Alexander
AU - Qureshi, Abrar A
AU - Robertson, Debbie
AU - Valdez, Hernan
AU - Tan, Huaming
AU - Wolk, Robert
N1 - Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
PY - 2016/11
Y1 - 2016/11
N2 - BACKGROUND: Psoriasis is a systemic inflammatory condition that is associated with a higher risk of cardiovascular (CV) disease. Tofacitinib is being investigated as a treatment for psoriasis.OBJECTIVE: We sought to evaluate the effects of tofacitinib on CV risk factors and major adverse CV events (MACEs) in patients with plaque psoriasis.METHODS: Changes in select CV risk factors and the incidence rate (IR) of MACEs were evaluated in patients who were treated with tofacitinib.RESULTS: Tofacitinib treatment was associated with small, dose-dependent increases in total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol, while the total/HDL cholesterol ratio was unchanged. There were no changes in blood pressure and glycated hemoglobin levels; C-reactive protein levels decreased. The IRs of a MACE were low and similar for both tofacitinib doses. Among 3623 subjects treated with tofacitinib, the total patient-years of exposure was 5204, with a median follow-up of 527 days, and the IR of MACEs was 0.37 (95% confidence interval, 0.22-0.57) patients with events per 100 patient-years.LIMITATIONS: There was relatively short follow-up time for patients who had MACEs.CONCLUSIONS: While treatment with tofacitinib is associated with a small increase in cholesterol levels, the total/HDL cholesterol ratio does not change, there are no unfavorable changes in several CV risk factors, and the incidence of MACEs is low.
AB - BACKGROUND: Psoriasis is a systemic inflammatory condition that is associated with a higher risk of cardiovascular (CV) disease. Tofacitinib is being investigated as a treatment for psoriasis.OBJECTIVE: We sought to evaluate the effects of tofacitinib on CV risk factors and major adverse CV events (MACEs) in patients with plaque psoriasis.METHODS: Changes in select CV risk factors and the incidence rate (IR) of MACEs were evaluated in patients who were treated with tofacitinib.RESULTS: Tofacitinib treatment was associated with small, dose-dependent increases in total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol, while the total/HDL cholesterol ratio was unchanged. There were no changes in blood pressure and glycated hemoglobin levels; C-reactive protein levels decreased. The IRs of a MACE were low and similar for both tofacitinib doses. Among 3623 subjects treated with tofacitinib, the total patient-years of exposure was 5204, with a median follow-up of 527 days, and the IR of MACEs was 0.37 (95% confidence interval, 0.22-0.57) patients with events per 100 patient-years.LIMITATIONS: There was relatively short follow-up time for patients who had MACEs.CONCLUSIONS: While treatment with tofacitinib is associated with a small increase in cholesterol levels, the total/HDL cholesterol ratio does not change, there are no unfavorable changes in several CV risk factors, and the incidence of MACEs is low.
KW - Adult
KW - Blood Pressure
KW - C-Reactive Protein
KW - Cardiovascular Diseases
KW - Cholesterol
KW - Clinical Trials, Phase II as Topic
KW - Clinical Trials, Phase III as Topic
KW - Comorbidity
KW - Dyslipidemias
KW - Female
KW - Hemoglobin A, Glycosylated
KW - Humans
KW - Male
KW - Metabolic Syndrome X
KW - Middle Aged
KW - Piperidines
KW - Protein Kinase Inhibitors
KW - Psoriasis
KW - Pyrimidines
KW - Pyrroles
KW - Risk Factors
KW - Treatment Outcome
KW - Triglycerides
KW - Journal Article
U2 - 10.1016/j.jaad.2016.06.012
DO - 10.1016/j.jaad.2016.06.012
M3 - Journal article
C2 - 27498960
VL - 75
SP - 897
EP - 905
JO - American Academy of Dermatology. Journal
JF - American Academy of Dermatology. Journal
SN - 0190-9622
IS - 5
ER -
ID: 177054476