Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

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Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. / Mitchell, Sarah J.; Madrigal-Matute, Julio; Scheibye-Knudsen, Morten; Fang, Evandro; Aon, Miguel; Gonzalez-Reyes, Jose A.; Cortassa, Sonia; Kaushik, Susmita; Gonzalez-Freire, Marta; Patel, Bindi; Wahl, Devin; Ali, Ahmed; Calvo-Rubio, Miguel; Buron, Maria I.; Guiterrez, Vincent; Ward, Theresa M.; Palacios, Hector H.; Cai, Huan; Frederick, David W.; Hine, Christopher; Broeskamp, Filomena; Habering, Lukas; Dawson, John; Beasley, T. Mark; Wan, Junxiang; Ikeno, Yuji; Hubbard, Gene; Becker, Kevin G.; Zhang, Yongqing; Bohr, Vilhelm A.; Longo, Dan L.; Navas, Placido; Ferrucci, Luigi; Sinclair, David A.; Cohen, Pinchas; Egan, Josephine M.; Mitchell, James R.; Baur, Joseph A.; Allison, David B.; Anson, R. Michael; Villalba, Jose M.; Madeo, Frank; Cuervo, Ana Maria; Pearson, Kevin J.; Ingram, Donald K.; Bernier, Michel; de Cabo, Rafael.

I: Cell Metabolism, Bind 23, Nr. 6, 14.06.2016, s. 1093-1112.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Mitchell, SJ, Madrigal-Matute, J, Scheibye-Knudsen, M, Fang, E, Aon, M, Gonzalez-Reyes, JA, Cortassa, S, Kaushik, S, Gonzalez-Freire, M, Patel, B, Wahl, D, Ali, A, Calvo-Rubio, M, Buron, MI, Guiterrez, V, Ward, TM, Palacios, HH, Cai, H, Frederick, DW, Hine, C, Broeskamp, F, Habering, L, Dawson, J, Beasley, TM, Wan, J, Ikeno, Y, Hubbard, G, Becker, KG, Zhang, Y, Bohr, VA, Longo, DL, Navas, P, Ferrucci, L, Sinclair, DA, Cohen, P, Egan, JM, Mitchell, JR, Baur, JA, Allison, DB, Anson, RM, Villalba, JM, Madeo, F, Cuervo, AM, Pearson, KJ, Ingram, DK, Bernier, M & de Cabo, R 2016, 'Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice', Cell Metabolism, bind 23, nr. 6, s. 1093-1112. https://doi.org/10.1016/j.cmet.2016.05.027

APA

Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., Gonzalez-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., Wahl, D., Ali, A., Calvo-Rubio, M., Buron, M. I., Guiterrez, V., Ward, T. M., Palacios, H. H., Cai, H., Frederick, D. W., ... de Cabo, R. (2016). Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metabolism, 23(6), 1093-1112. https://doi.org/10.1016/j.cmet.2016.05.027

Vancouver

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, Gonzalez-Reyes JA o.a. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metabolism. 2016 jun. 14;23(6):1093-1112. https://doi.org/10.1016/j.cmet.2016.05.027

Author

Mitchell, Sarah J. ; Madrigal-Matute, Julio ; Scheibye-Knudsen, Morten ; Fang, Evandro ; Aon, Miguel ; Gonzalez-Reyes, Jose A. ; Cortassa, Sonia ; Kaushik, Susmita ; Gonzalez-Freire, Marta ; Patel, Bindi ; Wahl, Devin ; Ali, Ahmed ; Calvo-Rubio, Miguel ; Buron, Maria I. ; Guiterrez, Vincent ; Ward, Theresa M. ; Palacios, Hector H. ; Cai, Huan ; Frederick, David W. ; Hine, Christopher ; Broeskamp, Filomena ; Habering, Lukas ; Dawson, John ; Beasley, T. Mark ; Wan, Junxiang ; Ikeno, Yuji ; Hubbard, Gene ; Becker, Kevin G. ; Zhang, Yongqing ; Bohr, Vilhelm A. ; Longo, Dan L. ; Navas, Placido ; Ferrucci, Luigi ; Sinclair, David A. ; Cohen, Pinchas ; Egan, Josephine M. ; Mitchell, James R. ; Baur, Joseph A. ; Allison, David B. ; Anson, R. Michael ; Villalba, Jose M. ; Madeo, Frank ; Cuervo, Ana Maria ; Pearson, Kevin J. ; Ingram, Donald K. ; Bernier, Michel ; de Cabo, Rafael. / Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. I: Cell Metabolism. 2016 ; Bind 23, Nr. 6. s. 1093-1112.

Bibtex

@article{99ca0c447a0e42218870b5294d011bff,
title = "Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice",
abstract = "Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However, there are a number of emerging experimental variables that alter CR responses. We investigated the role of sex, strain, and level of CR on health and survival in mice. CR did not always correlate with lifespan extension, although it consistently improved health across strains and sexes. Transcriptional and metabolomics changes driven by CR in liver indicated anaplerotic filling of the Krebs cycle together with fatty acid fueling of mitochondria. CR prevented ageassociated decline in the liver proteostasis network while increasing mitochondrial number, preserving mitochondrial ultrastructure and function with age. Abrogation of mitochondrial function negated life-prolonging effects of CR in yeast and worms. Our data illustrate the complexity of CR in the context of aging, with a clear separation of outcomes related to health and survival, highlighting complexities of translation of CR into human interventions.",
author = "Mitchell, {Sarah J.} and Julio Madrigal-Matute and Morten Scheibye-Knudsen and Evandro Fang and Miguel Aon and Gonzalez-Reyes, {Jose A.} and Sonia Cortassa and Susmita Kaushik and Marta Gonzalez-Freire and Bindi Patel and Devin Wahl and Ahmed Ali and Miguel Calvo-Rubio and Buron, {Maria I.} and Vincent Guiterrez and Ward, {Theresa M.} and Palacios, {Hector H.} and Huan Cai and Frederick, {David W.} and Christopher Hine and Filomena Broeskamp and Lukas Habering and John Dawson and Beasley, {T. Mark} and Junxiang Wan and Yuji Ikeno and Gene Hubbard and Becker, {Kevin G.} and Yongqing Zhang and Bohr, {Vilhelm A.} and Longo, {Dan L.} and Placido Navas and Luigi Ferrucci and Sinclair, {David A.} and Pinchas Cohen and Egan, {Josephine M.} and Mitchell, {James R.} and Baur, {Joseph A.} and Allison, {David B.} and Anson, {R. Michael} and Villalba, {Jose M.} and Frank Madeo and Cuervo, {Ana Maria} and Pearson, {Kevin J.} and Ingram, {Donald K.} and Michel Bernier and {de Cabo}, Rafael",
year = "2016",
month = jun,
day = "14",
doi = "10.1016/j.cmet.2016.05.027",
language = "English",
volume = "23",
pages = "1093--1112",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

AU - Mitchell, Sarah J.

AU - Madrigal-Matute, Julio

AU - Scheibye-Knudsen, Morten

AU - Fang, Evandro

AU - Aon, Miguel

AU - Gonzalez-Reyes, Jose A.

AU - Cortassa, Sonia

AU - Kaushik, Susmita

AU - Gonzalez-Freire, Marta

AU - Patel, Bindi

AU - Wahl, Devin

AU - Ali, Ahmed

AU - Calvo-Rubio, Miguel

AU - Buron, Maria I.

AU - Guiterrez, Vincent

AU - Ward, Theresa M.

AU - Palacios, Hector H.

AU - Cai, Huan

AU - Frederick, David W.

AU - Hine, Christopher

AU - Broeskamp, Filomena

AU - Habering, Lukas

AU - Dawson, John

AU - Beasley, T. Mark

AU - Wan, Junxiang

AU - Ikeno, Yuji

AU - Hubbard, Gene

AU - Becker, Kevin G.

AU - Zhang, Yongqing

AU - Bohr, Vilhelm A.

AU - Longo, Dan L.

AU - Navas, Placido

AU - Ferrucci, Luigi

AU - Sinclair, David A.

AU - Cohen, Pinchas

AU - Egan, Josephine M.

AU - Mitchell, James R.

AU - Baur, Joseph A.

AU - Allison, David B.

AU - Anson, R. Michael

AU - Villalba, Jose M.

AU - Madeo, Frank

AU - Cuervo, Ana Maria

AU - Pearson, Kevin J.

AU - Ingram, Donald K.

AU - Bernier, Michel

AU - de Cabo, Rafael

PY - 2016/6/14

Y1 - 2016/6/14

N2 - Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However, there are a number of emerging experimental variables that alter CR responses. We investigated the role of sex, strain, and level of CR on health and survival in mice. CR did not always correlate with lifespan extension, although it consistently improved health across strains and sexes. Transcriptional and metabolomics changes driven by CR in liver indicated anaplerotic filling of the Krebs cycle together with fatty acid fueling of mitochondria. CR prevented ageassociated decline in the liver proteostasis network while increasing mitochondrial number, preserving mitochondrial ultrastructure and function with age. Abrogation of mitochondrial function negated life-prolonging effects of CR in yeast and worms. Our data illustrate the complexity of CR in the context of aging, with a clear separation of outcomes related to health and survival, highlighting complexities of translation of CR into human interventions.

AB - Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However, there are a number of emerging experimental variables that alter CR responses. We investigated the role of sex, strain, and level of CR on health and survival in mice. CR did not always correlate with lifespan extension, although it consistently improved health across strains and sexes. Transcriptional and metabolomics changes driven by CR in liver indicated anaplerotic filling of the Krebs cycle together with fatty acid fueling of mitochondria. CR prevented ageassociated decline in the liver proteostasis network while increasing mitochondrial number, preserving mitochondrial ultrastructure and function with age. Abrogation of mitochondrial function negated life-prolonging effects of CR in yeast and worms. Our data illustrate the complexity of CR in the context of aging, with a clear separation of outcomes related to health and survival, highlighting complexities of translation of CR into human interventions.

U2 - 10.1016/j.cmet.2016.05.027

DO - 10.1016/j.cmet.2016.05.027

M3 - Journal article

C2 - 27304509

VL - 23

SP - 1093

EP - 1112

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 6

ER -

ID: 166500486