Effects of diabetes on brain metabolism - is brain glycogen a significant player?

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Effects of diabetes on brain metabolism - is brain glycogen a significant player? / Sickmann, Helle M; Waagepetersen, Helle S.

I: Metabolic Brain Disease, Bind 30, 2015, s. 335-343.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Sickmann, HM & Waagepetersen, HS 2015, 'Effects of diabetes on brain metabolism - is brain glycogen a significant player?', Metabolic Brain Disease, bind 30, s. 335-343. https://doi.org/10.1007/s11011-014-9546-z

APA

Sickmann, H. M., & Waagepetersen, H. S. (2015). Effects of diabetes on brain metabolism - is brain glycogen a significant player? Metabolic Brain Disease, 30, 335-343. https://doi.org/10.1007/s11011-014-9546-z

Vancouver

Sickmann HM, Waagepetersen HS. Effects of diabetes on brain metabolism - is brain glycogen a significant player? Metabolic Brain Disease. 2015;30:335-343. https://doi.org/10.1007/s11011-014-9546-z

Author

Sickmann, Helle M ; Waagepetersen, Helle S. / Effects of diabetes on brain metabolism - is brain glycogen a significant player?. I: Metabolic Brain Disease. 2015 ; Bind 30. s. 335-343.

Bibtex

@article{0a29cb0ce7474a39a0bd47fbdc2faaea,
title = "Effects of diabetes on brain metabolism - is brain glycogen a significant player?",
abstract = "Brain glycogen, being an intracellular glucose reservoir, contributes to maintain energy and neurotransmitter homeostasis under physiological as well as pathological conditions. Under conditions with a disturbance in systemic glucose metabolism such as in diabetes, the supply of glucose to the brain may be affected and have important impacts on brain metabolism and neurotransmission. This also implies that brain glycogen may serve an essential role in the diabetic state to sustain appropriate brain function. There are two main types of diabetes; type 1 and type 2 diabetes and both types may be associated with brain impairments e.g. cognitive decline and dementia. It is however, not clear how these impairments on brain function are linked to alterations in brain energy and neurotransmitter metabolism. In this review, we will illuminate how rodent diabetes models have contributed to a better understanding of how brain energy and neurotransmitter metabolism is affected in diabetes. There will be a particular focus on the role of brain glycogen to support glycolytic and TCA cycle activity as well as glutamate-glutamine cycle in type 1 and type 2 diabetes.",
author = "Sickmann, {Helle M} and Waagepetersen, {Helle S.}",
year = "2015",
doi = "10.1007/s11011-014-9546-z",
language = "English",
volume = "30",
pages = "335--343",
journal = "Metabolic Brain Disease",
issn = "0885-7490",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Effects of diabetes on brain metabolism - is brain glycogen a significant player?

AU - Sickmann, Helle M

AU - Waagepetersen, Helle S.

PY - 2015

Y1 - 2015

N2 - Brain glycogen, being an intracellular glucose reservoir, contributes to maintain energy and neurotransmitter homeostasis under physiological as well as pathological conditions. Under conditions with a disturbance in systemic glucose metabolism such as in diabetes, the supply of glucose to the brain may be affected and have important impacts on brain metabolism and neurotransmission. This also implies that brain glycogen may serve an essential role in the diabetic state to sustain appropriate brain function. There are two main types of diabetes; type 1 and type 2 diabetes and both types may be associated with brain impairments e.g. cognitive decline and dementia. It is however, not clear how these impairments on brain function are linked to alterations in brain energy and neurotransmitter metabolism. In this review, we will illuminate how rodent diabetes models have contributed to a better understanding of how brain energy and neurotransmitter metabolism is affected in diabetes. There will be a particular focus on the role of brain glycogen to support glycolytic and TCA cycle activity as well as glutamate-glutamine cycle in type 1 and type 2 diabetes.

AB - Brain glycogen, being an intracellular glucose reservoir, contributes to maintain energy and neurotransmitter homeostasis under physiological as well as pathological conditions. Under conditions with a disturbance in systemic glucose metabolism such as in diabetes, the supply of glucose to the brain may be affected and have important impacts on brain metabolism and neurotransmission. This also implies that brain glycogen may serve an essential role in the diabetic state to sustain appropriate brain function. There are two main types of diabetes; type 1 and type 2 diabetes and both types may be associated with brain impairments e.g. cognitive decline and dementia. It is however, not clear how these impairments on brain function are linked to alterations in brain energy and neurotransmitter metabolism. In this review, we will illuminate how rodent diabetes models have contributed to a better understanding of how brain energy and neurotransmitter metabolism is affected in diabetes. There will be a particular focus on the role of brain glycogen to support glycolytic and TCA cycle activity as well as glutamate-glutamine cycle in type 1 and type 2 diabetes.

U2 - 10.1007/s11011-014-9546-z

DO - 10.1007/s11011-014-9546-z

M3 - Journal article

C2 - 24771109

VL - 30

SP - 335

EP - 343

JO - Metabolic Brain Disease

JF - Metabolic Brain Disease

SN - 0885-7490

ER -

ID: 120585601