Effectiveness and acceptability of a pragmatic exercise intervention for patients with type 2 diabetes in specialized care
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Aims: Physical activity improves glycaemic control in type 2 diabetes (T2D), but adherence is low, and diabetes complications are barriers towards adopting physical activity. We investigated adherence and effects of individualized supervised exercise. Methods: Patients with intermediate (level 2) to high (level 3) risk of complications to T2D (stratified by Danish risk stratification model) were offered 12 weeks of exercise. Primary outcomes were working capacity assessed with the Åstrand-Rhyming cycling test (Åstrand), functional capacity assessed with the 30-second chair-stand test (30 s-CST) and health-related quality of life assessed with EuroQoL-5D-5L (EQ-5D-5L). Associations between stratification levels (2 vs 3) and drop-out, changes in 30 s-CST and EQ-5D-5L were analysed using multiple regression. Results: In total 350 patients accepted participation and 254 (73%) completed with 26 patients experiencing an adverse event. Odds ratio (OR) for non-completion were 1.82 [1.02–3.23] (p = 0.043) for patients stratified level 3 vs 2. Improvements were seen in Åstrand 2.71 [1.59; 3.83] ml O2/kg/min (p < 0.001), in 30 s-CST 2.34 [2.01; 2.67] repetitions (p < 0.001) and in EQ-5D-5L 0.01 (−0.05 to 0.11) (p = 0.002). There were no associations between changes and risk-stratification levels. Conclusions: Clinically relevant changes were seen after exercising regardless of the stratification levels in patients with intermediate to high risk of complications to T2D.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 109176 |
| Tidsskrift | Diabetes Research and Clinical Practice |
| Vol/bind | 183 |
| ISSN | 0168-8227 |
| DOI | |
| Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This work was supported by an unrestricted grant from t he Novo Nordisk Foundation .
Funding Information:
We thank the departments of physiotherapy on Nordsj?llands Hospital and Herlev-Gentofte Hospital for taking part in the exercise intervention and testing. S.G.N. and J.H.D contributed to the study design and recruitment of participants, including motivational interviewing and testing, exercise training and statistical analyses, researched the data and wrote the manuscript. S.S.J. contributed to recruitment of participants, performed screening, tests and exercise training and reviewed the manuscript. P.L.K contributed to data collection and reviewed/edited the manuscript. H.S. contributed to the data collection and reviewed/edited the manuscript. S.M. contributed to the study design, supervised the statistical analyses, contributed to the interpretation of the results, and reviewed/edited the manuscript. T.V. contributed to the study design, contributed to the interpretation of the results, and reviewed/edited the manuscript. S.M. and T.V. are the guarantors of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. This work was supported by an unrestricted grant from the Novo Nordisk Foundation.
Publisher Copyright:
© 2021 Elsevier B.V.
ID: 290110760