Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue

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Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue. / Bager Christensen, Ida; Blom, Ida; Dohlmann, Tine Lovsø; Finger, Fabian; W Helge, Jørn; Gerhart-Hines, Zachary; Dela, Flemming; Larsen, Steen.

I: Journal of Clinical Endocrinology and Metabolism, Bind 108, Nr. 10, 2023, s. e916-e922.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bager Christensen, I, Blom, I, Dohlmann, TL, Finger, F, W Helge, J, Gerhart-Hines, Z, Dela, F & Larsen, S 2023, 'Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue', Journal of Clinical Endocrinology and Metabolism, bind 108, nr. 10, s. e916-e922. https://doi.org/10.1210/clinem/dgad259

APA

Bager Christensen, I., Blom, I., Dohlmann, T. L., Finger, F., W Helge, J., Gerhart-Hines, Z., Dela, F., & Larsen, S. (2023). Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue. Journal of Clinical Endocrinology and Metabolism, 108(10), e916-e922. https://doi.org/10.1210/clinem/dgad259

Vancouver

Bager Christensen I, Blom I, Dohlmann TL, Finger F, W Helge J, Gerhart-Hines Z o.a. Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue. Journal of Clinical Endocrinology and Metabolism. 2023;108(10):e916-e922. https://doi.org/10.1210/clinem/dgad259

Author

Bager Christensen, Ida ; Blom, Ida ; Dohlmann, Tine Lovsø ; Finger, Fabian ; W Helge, Jørn ; Gerhart-Hines, Zachary ; Dela, Flemming ; Larsen, Steen. / Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue. I: Journal of Clinical Endocrinology and Metabolism. 2023 ; Bind 108, Nr. 10. s. e916-e922.

Bibtex

@article{74d6657da6b7436f8cf0c04b3b49c53c,
title = "Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue",
abstract = "BACKGROUND: Statin therapy has shown pleiotropic effects affecting both mitochondrial function and inflammatory status. However, few studies have investigated the concurrent effects of statin exposure on mitochondrial function and inflammatory status in human subcutaneous white adipose tissue.OBJECTIVES: In a cross-sectional study, we investigated the effects of simvastatin on mitochondrial function and inflammatory status in subcutaneous white adipose tissue of 55 human participants: 38 patients (19 female/19 male) in primary prevention with simvastatin (> 40 mg/day,  > 3 mo) and 17 controls (9 female/8 male) with elevated plasma cholesterol. The two groups were matched on age, BMI and VO2max.METHODS: Anthropometrics and fasting biochemical characteristics were measured. Mitochondrial respiratory capacity was assessed in white adipose tissue by high-resolution respirometry. Subcutaneous white adipose tissue expression of the inflammatory markers IL-6, CCL-2, CCL-5, TNFα, IL-10 and IL-4 was analysed by qPCR.RESULTS: Simvastatin-treated patients showed lower plasma cholesterol (p < 0.0001), LDL (p < 0.0001) and triglyceride levels (p = 0.0116) than controls. Simvastatin-treated patients had a lower oxidative phosphorylation capacity of mitochondrial complex II (p = 0.0001 when normalised to wet weight, p < 0.0001 when normalised to citrate synthase activity (intrinsic)) and a lower intrinsic mitochondrial electron transport system capacity (p = 0.0004). Simvastatin-treated patients showed higher IL-6 expression than controls (p = 0.0202).CONCLUSION: Simvastatin treatment was linked to mitochondrial respiratory capacity in human subcutaneous white adipose tissue, but no clear link was found between statin exposure, respiratory changes and inflammatory status of adipose tissue.",
author = "{Bager Christensen}, Ida and Ida Blom and Dohlmann, {Tine Lovs{\o}} and Fabian Finger and {W Helge}, J{\o}rn and Zachary Gerhart-Hines and Flemming Dela and Steen Larsen",
note = "{\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2023",
doi = "10.1210/clinem/dgad259",
language = "English",
volume = "108",
pages = "e916--e922",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "10",

}

RIS

TY - JOUR

T1 - Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue

AU - Bager Christensen, Ida

AU - Blom, Ida

AU - Dohlmann, Tine Lovsø

AU - Finger, Fabian

AU - W Helge, Jørn

AU - Gerhart-Hines, Zachary

AU - Dela, Flemming

AU - Larsen, Steen

N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2023

Y1 - 2023

N2 - BACKGROUND: Statin therapy has shown pleiotropic effects affecting both mitochondrial function and inflammatory status. However, few studies have investigated the concurrent effects of statin exposure on mitochondrial function and inflammatory status in human subcutaneous white adipose tissue.OBJECTIVES: In a cross-sectional study, we investigated the effects of simvastatin on mitochondrial function and inflammatory status in subcutaneous white adipose tissue of 55 human participants: 38 patients (19 female/19 male) in primary prevention with simvastatin (> 40 mg/day,  > 3 mo) and 17 controls (9 female/8 male) with elevated plasma cholesterol. The two groups were matched on age, BMI and VO2max.METHODS: Anthropometrics and fasting biochemical characteristics were measured. Mitochondrial respiratory capacity was assessed in white adipose tissue by high-resolution respirometry. Subcutaneous white adipose tissue expression of the inflammatory markers IL-6, CCL-2, CCL-5, TNFα, IL-10 and IL-4 was analysed by qPCR.RESULTS: Simvastatin-treated patients showed lower plasma cholesterol (p < 0.0001), LDL (p < 0.0001) and triglyceride levels (p = 0.0116) than controls. Simvastatin-treated patients had a lower oxidative phosphorylation capacity of mitochondrial complex II (p = 0.0001 when normalised to wet weight, p < 0.0001 when normalised to citrate synthase activity (intrinsic)) and a lower intrinsic mitochondrial electron transport system capacity (p = 0.0004). Simvastatin-treated patients showed higher IL-6 expression than controls (p = 0.0202).CONCLUSION: Simvastatin treatment was linked to mitochondrial respiratory capacity in human subcutaneous white adipose tissue, but no clear link was found between statin exposure, respiratory changes and inflammatory status of adipose tissue.

AB - BACKGROUND: Statin therapy has shown pleiotropic effects affecting both mitochondrial function and inflammatory status. However, few studies have investigated the concurrent effects of statin exposure on mitochondrial function and inflammatory status in human subcutaneous white adipose tissue.OBJECTIVES: In a cross-sectional study, we investigated the effects of simvastatin on mitochondrial function and inflammatory status in subcutaneous white adipose tissue of 55 human participants: 38 patients (19 female/19 male) in primary prevention with simvastatin (> 40 mg/day,  > 3 mo) and 17 controls (9 female/8 male) with elevated plasma cholesterol. The two groups were matched on age, BMI and VO2max.METHODS: Anthropometrics and fasting biochemical characteristics were measured. Mitochondrial respiratory capacity was assessed in white adipose tissue by high-resolution respirometry. Subcutaneous white adipose tissue expression of the inflammatory markers IL-6, CCL-2, CCL-5, TNFα, IL-10 and IL-4 was analysed by qPCR.RESULTS: Simvastatin-treated patients showed lower plasma cholesterol (p < 0.0001), LDL (p < 0.0001) and triglyceride levels (p = 0.0116) than controls. Simvastatin-treated patients had a lower oxidative phosphorylation capacity of mitochondrial complex II (p = 0.0001 when normalised to wet weight, p < 0.0001 when normalised to citrate synthase activity (intrinsic)) and a lower intrinsic mitochondrial electron transport system capacity (p = 0.0004). Simvastatin-treated patients showed higher IL-6 expression than controls (p = 0.0202).CONCLUSION: Simvastatin treatment was linked to mitochondrial respiratory capacity in human subcutaneous white adipose tissue, but no clear link was found between statin exposure, respiratory changes and inflammatory status of adipose tissue.

U2 - 10.1210/clinem/dgad259

DO - 10.1210/clinem/dgad259

M3 - Journal article

C2 - 37161534

VL - 108

SP - e916-e922

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 10

ER -

ID: 348166779