Early suppression policies protected pregnant women from COVID-19 in 2020: A population-based surveillance from the Nordic countries

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  • Reetta Varpula
  • Outi Äyräs
  • Kari Klungsøyr
  • Teresia Svanvik
  • Julia Kanerva
  • Eva Jonasdottir
  • Camilla Tjønneland Mentzoni
  • Lars Thurn
  • Elin Jones
  • Lisa Fredriksson
  • Karin Pettersson
  • Lill Trine Nyfløt
  • Siri Vangen
  • Kjerstine Røe
  • Pétur B. Júlíusson
  • Karin Källén
  • Mika Gissler
  • Aura Pyykönen
  • Maija Jakobsson
  • Hilde Marie Engjom
Introduction
The Coronavirus 2019 Disease (COVID-19) pandemic reached the Nordic countries in March 2020. Public health interventions to limit viral transmission varied across different countries both in timing and in magnitude. Interventions indicated by an Oxford Stringency Index ≥50 were implemented early (March 13–17, 2020) in Denmark, Finland, Norway and Iceland, and on March 26, 2020 in Sweden. The aim of the current study was to assess the incidence of COVID-19-related admissions of pregnant women in the Nordic countries in relation to the different national public health strategies during the first year of the pandemic.

Material and methods
This is a meta-analysis of population-based cohort studies in the five Nordic countries with national or regional surveillance in the Nordic Obstetric Surveillance System (NOSS) collaboration: national data from Denmark, Finland, Iceland and Norway, and regional data covering 31% of births in Sweden. The source population consisted of women giving birth in the included areas March 1–December 31, 2020. Pregnant women with a positive SARS-CoV-2 PCR test ≤14 days before hospital admission were included, and admissions were stratified as either COVID-19-related or non-COVID (other obstetric healthcare). Information about public health policies was retrieved retrospectively.

Results
In total, 392 382 maternities were considered. Of these, 600 women were diagnosed with SARS-CoV-2 infection and 137 (22.8%) were admitted for COVID-19 symptoms. The pooled incidence of COVID-19 admissions per 1000 maternities was 0.5 (95% confidence interval [CI] 0.2 to 1.2, I2 = 77.6, tau2 = 0.68, P = 0.0), ranging from no admissions in Iceland to 1.9 admissions in the Swedish regions. Interventions to restrict viral transmission were less stringent in Sweden than in the other Nordic countries.

Conclusions
There was a clear variation in pregnant women's risk of COVID-19 admission across countries with similar healthcare systems but different public health interventions to limit viral transmission. The meta-analysis indicates that early suppression policies protected pregnant women from severe COVID-19 disease prior to the availability of individual protection with vaccines.
OriginalsprogEngelsk
TidsskriftActa Obstetricia et Gynecologica Scandinavica
Antal sider10
ISSN0001-6349
DOI
StatusAccepteret/In press - 2024

Bibliografisk note

Funding Information:
The study received support from the NFOG Fund (grant no. 6506). OÄ received a grant from the Finnish Medical Society and the Finnish study was also supported by a Helsinki University Hospital Grant. HME and CTM received research funding from the Norwegian Research Council (grant no 320181). The Danish study was supported by a grant from The Region of Southern Denmark and Region Zealand's shared fund for joint health research projects (Reg. no. A767). The clinical trial management software EASYTRIAL was provided for free for COVID‐19 research projects and was used for data management in Denmark.

Publisher Copyright:
© 2024 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).

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