Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Early development of tendinopathy in humans : Sequence of pathological changes in structure and tissue turnover signaling. / Tran, Peter H.T.; Malmgaard-Clausen, Nikolaj M.; Puggaard, Rikke S.; Svensson, René B.; Nybing, Janus D.; Hansen, Philip; Schjerling, Peter; Zinglersen, Amanda H.; Couppé, Christian; Boesen, Mikael; Magnusson, S. Peter; Kjaer, Michael.
I: FASEB Journal, Bind 34, Nr. 1, 2020, s. 776-788.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Early development of tendinopathy in humans
T2 - Sequence of pathological changes in structure and tissue turnover signaling
AU - Tran, Peter H.T.
AU - Malmgaard-Clausen, Nikolaj M.
AU - Puggaard, Rikke S.
AU - Svensson, René B.
AU - Nybing, Janus D.
AU - Hansen, Philip
AU - Schjerling, Peter
AU - Zinglersen, Amanda H.
AU - Couppé, Christian
AU - Boesen, Mikael
AU - Magnusson, S. Peter
AU - Kjaer, Michael
PY - 2020
Y1 - 2020
N2 - Overloading of tendon tissue with resulting chronic pain (tendinopathy) is a common disorder in occupational-, leisure- and sports-activity, but its pathogenesis remains poorly understood. To investigate the very early phase of tendinopathy, Achilles and patellar tendons were investigated in 200 physically active patients and 50 healthy control persons. Patients were divided into three groups: symptoms for 0-1 months (T1), 1-2 months (T2) or 2-3 months (T3). Tendinopathic Achilles tendon cross-sectional area determined by ultrasonography (US) was ~25% larger than in healthy control persons. Both Achilles and patellar anterior-posterior diameter were elevated in tendinopathy, and only later in Achilles was the width increased. Increased tendon size was accompanied by an increase in hypervascularization (US Doppler flow) without any change in mRNA for angiogenic factors. From patellar biopsies taken bilaterally, mRNA for most growth factors and tendon components remained unchanged (except for TGF-beta1 and substance-P) in early tendinopathy. Tendon stiffness remained unaltered over the first three months of tendinopathy and was similar to the asymptomatic contra-lateral tendon. In conclusion, this suggests that tendinopathy pathogenesis represents a disturbed tissue homeostasis with fluid accumulation. The disturbance is likely induced by repeated mechanical overloading rather than a partial rupture of the tendon.
AB - Overloading of tendon tissue with resulting chronic pain (tendinopathy) is a common disorder in occupational-, leisure- and sports-activity, but its pathogenesis remains poorly understood. To investigate the very early phase of tendinopathy, Achilles and patellar tendons were investigated in 200 physically active patients and 50 healthy control persons. Patients were divided into three groups: symptoms for 0-1 months (T1), 1-2 months (T2) or 2-3 months (T3). Tendinopathic Achilles tendon cross-sectional area determined by ultrasonography (US) was ~25% larger than in healthy control persons. Both Achilles and patellar anterior-posterior diameter were elevated in tendinopathy, and only later in Achilles was the width increased. Increased tendon size was accompanied by an increase in hypervascularization (US Doppler flow) without any change in mRNA for angiogenic factors. From patellar biopsies taken bilaterally, mRNA for most growth factors and tendon components remained unchanged (except for TGF-beta1 and substance-P) in early tendinopathy. Tendon stiffness remained unaltered over the first three months of tendinopathy and was similar to the asymptomatic contra-lateral tendon. In conclusion, this suggests that tendinopathy pathogenesis represents a disturbed tissue homeostasis with fluid accumulation. The disturbance is likely induced by repeated mechanical overloading rather than a partial rupture of the tendon.
KW - clinical
KW - inflammation
KW - mRNA
KW - tendinopathy
KW - ultrasound
U2 - 10.1096/fj.201901309R
DO - 10.1096/fj.201901309R
M3 - Journal article
C2 - 31914656
AN - SCOPUS:85077741381
VL - 34
SP - 776
EP - 788
JO - F A S E B Journal
JF - F A S E B Journal
SN - 0892-6638
IS - 1
ER -
ID: 253234440