Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice

Early detection of response to experimental chemotherapeutic Top216 with [¹⁸F]FLT and [¹⁸F]FDG PET in human ovary cancer xenografts in mice

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Wessel, Mette Munk
Kamille Dumong Erichsen
Björkling, Fredrik
Jacob Madsen
Peter Buhl Jensen
Højgaard, Liselotte
Maxwell Sehested
Kjær, Andreas

3'-Deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use (18)F-FLT positron emission tomography (PET) to study treatment responses to a new anti-cancer compound. To do so, we studied early anti-proliferative effects of the experimental chemotherapy Top216 non-invasively by PET.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	5
Udgave nummer	9
Sider (fra-til)	e12965
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0012965
Status	Udgivet - 1 jan. 2010

ID: 34044950