Early- and late-onset posttransplant lymphoproliferative disorders among adult kidney and liver transplant recipients
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Objectives: Posttransplant lymphoproliferative disorder (PTLD) in solid organ transplant recipients has a high mortality and may present early (<2 years) or late (≥2 years) posttransplantation. We investigated the clinical characteristics of early and late PTLD among kidney and liver transplant recipients. Methods: Recipients, transplanted at Rigshospitalet, with PTLD development as adults from January 2010 to August 2020, were included. Clinical characteristics, laboratory parameters, and pathology of early and late PTLD were compared. Results: Thirty-one PTLD cases were detected where 10 (32%) were early and 21 (68%) were late PTLD. EBV DNA in plasma was detected in 78% versus 28% in early and late PTLD (p =.037). None of the recipients with early PTLD and nine recipients with late PTLD (47%) had Ann Arbor stage IV at the time of their diagnosis (p =.006). Cyclophosphamid–Hydroxyrubicin–Oncovin–Prednisolon was used for treatment in 10 (48%) recipients with late PTLD (p = 0.032) only. There was no difference in mortality between the two groups. Conclusions: Recipients with late PTLD had a lower prevalence of detectable EBV DNA in plasma, were diagnosed with more advanced disease, and were more frequently treated with chemotherapy compared to recipients with early PTLD.
Originalsprog | Engelsk |
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Bogserie | European Journal of Haematology |
Vol/bind | 109 |
Udgave nummer | 4 |
Sider (fra-til) | 343-350 |
Antal sider | 8 |
ISSN | 0902-4441 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
NW has received a grant from the Danish National Research foundation (DNRF no 126). SDN has received a grant from the Novo Nordic Foundation.
Publisher Copyright:
© 2022 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.
ID: 320651417