TY - JOUR

T1 - Dynamic SPECT of the brain using a lipophilic technetium-99m complex, PnAO

AU - Holm, S

AU - Andersen, A R

AU - Vorstrup, S

AU - Lassen, N A

AU - Paulson, O B

AU - Holmes, R A

PY - 1985/10

Y1 - 1985/10

N2 - The lipophilic 99mTc-labeled oxime propylene amine oxime (PnAO) should, according to recent reports behave like 133Xe in the human brain. This study compares SPECT images of the two tracers in six subjects: four stroke cases, one transitory ischemic attack case and one normal subject. Technetium-99m PnAO was injected i.v. as a bolus of 15 to 25 mCi. The distribution was followed over 10-sec intervals using a highly sensitive, rapidly rotating SPECT (Tomomatic 64) and compared to 133Xe flow maps. Upon arrival of the PnAO bolus to the brain, a high uptake was found in brain tissue with high cerebral blood flow followed by rapid washout. In the stroke cases, low flow areas were equally well visualized by both tracers. Two dissimilarities were seen in the initial pictures: PnAO visualized the cerebral veins and showed a lesser contrast of gray:white matter uptake. The results suggest that PnAO has a high yet incomplete brain extraction yielding a flow dominated initial distribution with limitations mentioned.

AB - The lipophilic 99mTc-labeled oxime propylene amine oxime (PnAO) should, according to recent reports behave like 133Xe in the human brain. This study compares SPECT images of the two tracers in six subjects: four stroke cases, one transitory ischemic attack case and one normal subject. Technetium-99m PnAO was injected i.v. as a bolus of 15 to 25 mCi. The distribution was followed over 10-sec intervals using a highly sensitive, rapidly rotating SPECT (Tomomatic 64) and compared to 133Xe flow maps. Upon arrival of the PnAO bolus to the brain, a high uptake was found in brain tissue with high cerebral blood flow followed by rapid washout. In the stroke cases, low flow areas were equally well visualized by both tracers. Two dissimilarities were seen in the initial pictures: PnAO visualized the cerebral veins and showed a lesser contrast of gray:white matter uptake. The results suggest that PnAO has a high yet incomplete brain extraction yielding a flow dominated initial distribution with limitations mentioned.

KW - Adult

KW - Brain/diagnostic imaging

KW - Cerebrovascular Disorders/diagnostic imaging

KW - Humans

KW - Ischemic Attack, Transient/diagnostic imaging

KW - Middle Aged

KW - Organotechnetium Compounds

KW - Oximes/metabolism

KW - Technetium/metabolism

KW - Tomography, Emission-Computed

KW - Xenon Radioisotopes/metabolism

M3 - Journal article

C2 - 3876414

VL - 26

SP - 1129

EP - 1134

JO - The Journal of Nuclear Medicine

JF - The Journal of Nuclear Medicine

SN - 0161-5505

IS - 10

ER -