Does glucose variability influence the relationship between mean plasma glucose and HbA1c levels in type 1 and type 2 diabetic patients?

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Does glucose variability influence the relationship between mean plasma glucose and HbA1c levels in type 1 and type 2 diabetic patients? / ADAG Study Group.

I: Diabetes Care. Supplement, Bind 34, Nr. 8, 08.2011, s. 1843-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

ADAG Study Group 2011, 'Does glucose variability influence the relationship between mean plasma glucose and HbA1c levels in type 1 and type 2 diabetic patients?', Diabetes Care. Supplement, bind 34, nr. 8, s. 1843-7. https://doi.org/10.2337/dc10-2217

APA

ADAG Study Group (2011). Does glucose variability influence the relationship between mean plasma glucose and HbA1c levels in type 1 and type 2 diabetic patients? Diabetes Care. Supplement, 34(8), 1843-7. https://doi.org/10.2337/dc10-2217

Vancouver

ADAG Study Group. Does glucose variability influence the relationship between mean plasma glucose and HbA1c levels in type 1 and type 2 diabetic patients? Diabetes Care. Supplement. 2011 aug.;34(8):1843-7. https://doi.org/10.2337/dc10-2217

Author

ADAG Study Group. / Does glucose variability influence the relationship between mean plasma glucose and HbA1c levels in type 1 and type 2 diabetic patients?. I: Diabetes Care. Supplement. 2011 ; Bind 34, Nr. 8. s. 1843-7.

Bibtex

@article{c8ac30f87c984799bc54dd30f838c0af,

title = "Does glucose variability influence the relationship between mean plasma glucose and HbA1c levels in type 1 and type 2 diabetic patients?",

abstract = "OBJECTIVE: The A1C-Derived Average Glucose (ADAG) study demonstrated a linear relationship between HbA(1c) and mean plasma glucose (MPG). As glucose variability (GV) may contribute to glycation, we examined the association of several glucose variability indices and the MPG-HbA(1c) relationship.RESEARCH DESIGN AND METHODS: Analyses included 268 patients with type 1 diabetes and 159 with type 2 diabetes. MPG during 3 months was calculated from 7-point self-monitored plasma glucose and continuous glucose monitoring. We calculated three different measures of GV and used a multiple-step regression model to determine the contribution of the respective GV measures to the MPG-HbA(1c) relationship.RESULTS: GV, as reflected by SD and continuous overlapping net glycemic action, had a significant effect on the MPG-HbA(1c) relationship in type 1 diabetic patients so that high GV led to a higher HbA(1c) level for the same MPG. In type 1 diabetes, the impact of confounding and effect modification of a low versus high SD at an MPG level of 160 mg/dL on the HbA(1c) level is 7.02 vs. 7.43 and 6.96 vs. 7.41. All GV measures showed the same tendency.CONCLUSIONS: In only type 1 diabetic patients, GV shows a significant interaction with MPG in the association with HbA(1c). This effect is more pronounced at higher HbA(1c) levels. However, the impact of GV on the HbA(1c) level in type 1 diabetes is modest, particularly when HbA(1c) is close to the treatment target of 7%.",

keywords = "Adolescent, Adult, Aged, Blood Glucose/metabolism, Diabetes Mellitus, Type 1/blood, Diabetes Mellitus, Type 2/blood, Female, Glycated Hemoglobin A/metabolism, Humans, Male, Middle Aged, Young Adult",

author = "Kuenen, {Judith C} and Rikke Borg and Kuik, {Dirk J} and Hui Zheng and David Schoenfeld and Michaela Diamant and Nathan, {David M} and Heine, {Robert J} and {ADAG Study Group}",

year = "2011",

month = aug,

doi = "10.2337/dc10-2217",

language = "English",

volume = "34",

pages = "1843--7",

journal = "Diabetes Care",

issn = "1935-5548",

publisher = "American Diabetes Association",

number = "8",