Do WHO criteria for gestational diabetes fit a rural population in Tanzania? – A follow-up study assessing mother and child health six years after a pregnancy diagnosed with gestational diabetes
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Do WHO criteria for gestational diabetes fit a rural population in Tanzania? – A follow-up study assessing mother and child health six years after a pregnancy diagnosed with gestational diabetes. / Eriksen, Camilla Byskou; Minja, Daniel Thomas; Christensen, Dirk Lund; Bygbjerg, Ib Christian; Damm, Peter; Schmiegelow, Christentze; Grunnet, Louise Groth; Hjort, Line.
I: Diabetes Research and Clinical Practice, Bind 211, 111657, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Do WHO criteria for gestational diabetes fit a rural population in Tanzania? – A follow-up study assessing mother and child health six years after a pregnancy diagnosed with gestational diabetes
AU - Eriksen, Camilla Byskou
AU - Minja, Daniel Thomas
AU - Christensen, Dirk Lund
AU - Bygbjerg, Ib Christian
AU - Damm, Peter
AU - Schmiegelow, Christentze
AU - Grunnet, Louise Groth
AU - Hjort, Line
N1 - Publisher Copyright: © 2024
PY - 2024
Y1 - 2024
N2 - Aims and Methods: In low- and middle- income countries (LMICs) consequences of gestational diabetes (GDM) is understudied. Using a prospective cohort of mothers (n = 197) and children (n = 251), from rural north-eastern Tanzania, we assessed prediabetes and type 2 diabetes (T2D) prevalence six years after a pregnancy with/without GDM. Results: The prevalence of prediabetes (49.4 % vs. 46.4 %) or T2D (20.0 % vs. 16.1 %), p ≥ 0.36, based on fasting plasma glucose (FPG) or HbA1c levels (prediabetes: 16.9 % vs. 13.8 % and T2D 1.2 % vs. 0 %, p = 0.47), and cardio-metabolic health parameters, were similar between women with/without previous GDM. These results were supported by similar perinatal outcomes and child health at follow-up. The overall prevalence of prediabetes/T2D was high, but no differences in other cardio-metabolic risk markers were observed in women with prediabetes/T2D compared to women with normal glucose tolerance. Conclusions: Despite high prevalence of GDM among Tanzanian women, the diagnosis was not associated with adverse pregnancy outcomes, nor with increased risk of prediabetes or T2D at follow-up. FPG and HbA1c may be poor markers for diabetes in this population, and further follow-up studies with longer time intervals are warranted to evaluate which GDM diagnostic criteria are most optimal for women in rural Tanzania and similar LMIC settings.
AB - Aims and Methods: In low- and middle- income countries (LMICs) consequences of gestational diabetes (GDM) is understudied. Using a prospective cohort of mothers (n = 197) and children (n = 251), from rural north-eastern Tanzania, we assessed prediabetes and type 2 diabetes (T2D) prevalence six years after a pregnancy with/without GDM. Results: The prevalence of prediabetes (49.4 % vs. 46.4 %) or T2D (20.0 % vs. 16.1 %), p ≥ 0.36, based on fasting plasma glucose (FPG) or HbA1c levels (prediabetes: 16.9 % vs. 13.8 % and T2D 1.2 % vs. 0 %, p = 0.47), and cardio-metabolic health parameters, were similar between women with/without previous GDM. These results were supported by similar perinatal outcomes and child health at follow-up. The overall prevalence of prediabetes/T2D was high, but no differences in other cardio-metabolic risk markers were observed in women with prediabetes/T2D compared to women with normal glucose tolerance. Conclusions: Despite high prevalence of GDM among Tanzanian women, the diagnosis was not associated with adverse pregnancy outcomes, nor with increased risk of prediabetes or T2D at follow-up. FPG and HbA1c may be poor markers for diabetes in this population, and further follow-up studies with longer time intervals are warranted to evaluate which GDM diagnostic criteria are most optimal for women in rural Tanzania and similar LMIC settings.
KW - Children
KW - Diagnosis criteria
KW - Follow-up
KW - GDM prevalence
KW - Gestational diabetes mellitus
KW - Low- and Middle-income countries
KW - Mothers
KW - Prediabetes
KW - Pregnancy
KW - Sub-Saharan Africa
KW - Type 2 diabetes mellitus
U2 - 10.1016/j.diabres.2024.111657
DO - 10.1016/j.diabres.2024.111657
M3 - Journal article
C2 - 38583780
AN - SCOPUS:85189672073
VL - 211
JO - Diabetes Research and Clinical Practice. Supplement
JF - Diabetes Research and Clinical Practice. Supplement
SN - 1572-1671
M1 - 111657
ER -
ID: 388830958