DNA replication stress and its impact on chromosome segregation and tumorigenesis
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DNA replication stress and its impact on chromosome segregation and tumorigenesis. / Zhang, Bi Ning; Bueno Venegas, Andrés; Hickson, Ian D.; Chu, Wai Kit.
I: Seminars in Cancer Biology, Bind 55, 2019, s. 61-69.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - DNA replication stress and its impact on chromosome segregation and tumorigenesis
AU - Zhang, Bi Ning
AU - Bueno Venegas, Andrés
AU - Hickson, Ian D.
AU - Chu, Wai Kit
PY - 2019
Y1 - 2019
N2 - Genome instability and cell cycle dysregulation are commonly associated with cancer. DNA replication stress driven by oncogene activation during tumorigenesis is now well established as a source of genome instability. Replication stress generates DNA damage not only during S phase, but also in the subsequent mitosis, where it impacts adversely on chromosome segregation. Some regions of the genome seem particularly sensitive to replication stress-induced instability; most notably, chromosome fragile sites. In this article, we review some of the important issues that have emerged in recent years concerning DNA replication stress and fragile site expression, as well as how chromosome instability is minimized by a family of ring-shaped protein complexes known as SMC proteins. Understanding how replication stress impacts on S phase and mitosis in cancer should provide opportunities for the development of novel and tumour-specific treatments.
AB - Genome instability and cell cycle dysregulation are commonly associated with cancer. DNA replication stress driven by oncogene activation during tumorigenesis is now well established as a source of genome instability. Replication stress generates DNA damage not only during S phase, but also in the subsequent mitosis, where it impacts adversely on chromosome segregation. Some regions of the genome seem particularly sensitive to replication stress-induced instability; most notably, chromosome fragile sites. In this article, we review some of the important issues that have emerged in recent years concerning DNA replication stress and fragile site expression, as well as how chromosome instability is minimized by a family of ring-shaped protein complexes known as SMC proteins. Understanding how replication stress impacts on S phase and mitosis in cancer should provide opportunities for the development of novel and tumour-specific treatments.
KW - Common fragile sites
KW - DNA replication stress
KW - MiDAS
KW - SMC proteins
U2 - 10.1016/j.semcancer.2018.04.005
DO - 10.1016/j.semcancer.2018.04.005
M3 - Journal article
C2 - 29692334
AN - SCOPUS:85046161578
VL - 55
SP - 61
EP - 69
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
SN - 1044-579X
ER -
ID: 201674967