DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
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DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia. / Borssén, Magnus; Nordlund, Jessica; Haider, Zahra; Landfors, Mattias; Larsson, Pär; Kanerva, Jukka; Schmiegelow, Kjeld; Flaegstad, Trond; Jónsson, Ólafur Gísli; Frost, Britt Marie; Palle, Josefine; Forestier, Erik; Heyman, Mats; Hultdin, Magnus; Lönnerholm, Gudmar; Degerman, Sofie.
I: Clinical Epigenetics, Bind 10, 31, 2018.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
AU - Borssén, Magnus
AU - Nordlund, Jessica
AU - Haider, Zahra
AU - Landfors, Mattias
AU - Larsson, Pär
AU - Kanerva, Jukka
AU - Schmiegelow, Kjeld
AU - Flaegstad, Trond
AU - Jónsson, Ólafur Gísli
AU - Frost, Britt Marie
AU - Palle, Josefine
AU - Forestier, Erik
AU - Heyman, Mats
AU - Hultdin, Magnus
AU - Lönnerholm, Gudmar
AU - Degerman, Sofie
PY - 2018
Y1 - 2018
N2 - Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. Results: Among the 137 patients that later relapsed, patients with a CIMP- profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.
AB - Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. Results: Among the 137 patients that later relapsed, patients with a CIMP- profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.
KW - BCP-ALL
KW - CIMP
KW - DNA methylation
KW - Prognosis
KW - Relapse
KW - Risk stratification
U2 - 10.1186/s13148-018-0466-3
DO - 10.1186/s13148-018-0466-3
M3 - Journal article
C2 - 29515676
AN - SCOPUS:85043307665
VL - 10
JO - Clinical Epigenetics (Print)
JF - Clinical Epigenetics (Print)
SN - 1868-7075
M1 - 31
ER -
ID: 200342712