Disentangling host–microbiota complexity through hologenomics

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Research on animal–microbiota interactions has become a central topic in biological sciences because of its relevance to basic eco-evolutionary processes and applied questions in agriculture and health. However, animal hosts and their associated microbial communities are still seldom studied in a systemic fashion. Hologenomics, the integrated study of the genetic features of a eukaryotic host alongside that of its associated microbes, is becoming a feasible — yet still underexploited — approach that overcomes this limitation. Acknowledging the biological and genetic properties of both hosts and microbes, along with the advantages and disadvantages of implemented techniques, is essential for designing optimal studies that enable some of the major questions in biology to be addressed.

TidsskriftNature Reviews Genetics
Udgave nummer5
Sider (fra-til)281-297
Antal sider17
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
The authors thank the Danish National Research Foundation award DNRF143 ‘A Center for Evolutionary Hologenomics’ for funding their research. A.A. acknowledges Lundbeckfonden grant R250-2017-1351. A.A., M.T.L. and M.T.P.G. were supported by the European Union (H2020-SFS-2018-1 project HoloFood-817729). M.T.L. and M.T.P.G. acknowledge the FHF (Norwegian Seafood Research Fund; “HoloFish”, grant No. 901436). S.B.A. acknowledges Lundbeckfonden Fellowship R335-2019-1513 ‘Understanding the Health Effects of Microbial Interactions’ and Independent Research Council Denmark Sapere Aude grant 9064-00029B ‘Understanding the Effects of Microbial Interactions on Host Health’.

Publisher Copyright:
© 2021, Springer Nature Limited.

ID: 283213384