Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics

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Standard

Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics. / Stampe, Niels Kjær; Ottenheijm, Maud Eline; Drici, Lylia; Albrechtsen, Nicolai J. Wewer; Nielsen, Annelaura Bach; Christoffersen, Christina; Warming, Peder Emil; Engstrøm, Thomas; Winkel, Bo Gregers; Jabbari, Reza; Tfelt-Hansen, Jacob; Glinge, Charlotte.

I: European Heart Journal: Acute Cardiovascular Care, Bind 13, Nr. 3, 2024, s. 264–272.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Stampe, NK, Ottenheijm, ME, Drici, L, Albrechtsen, NJW, Nielsen, AB, Christoffersen, C, Warming, PE, Engstrøm, T, Winkel, BG, Jabbari, R, Tfelt-Hansen, J & Glinge, C 2024, 'Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics', European Heart Journal: Acute Cardiovascular Care, bind 13, nr. 3, s. 264–272. https://doi.org/10.1093/ehjacc/zuad125

APA

Stampe, N. K., Ottenheijm, M. E., Drici, L., Albrechtsen, N. J. W., Nielsen, A. B., Christoffersen, C., Warming, P. E., Engstrøm, T., Winkel, B. G., Jabbari, R., Tfelt-Hansen, J., & Glinge, C. (2024). Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics. European Heart Journal: Acute Cardiovascular Care, 13(3), 264–272. https://doi.org/10.1093/ehjacc/zuad125

Vancouver

Stampe NK, Ottenheijm ME, Drici L, Albrechtsen NJW, Nielsen AB, Christoffersen C o.a. Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics. European Heart Journal: Acute Cardiovascular Care. 2024;13(3):264–272. https://doi.org/10.1093/ehjacc/zuad125

Author

Stampe, Niels Kjær ; Ottenheijm, Maud Eline ; Drici, Lylia ; Albrechtsen, Nicolai J. Wewer ; Nielsen, Annelaura Bach ; Christoffersen, Christina ; Warming, Peder Emil ; Engstrøm, Thomas ; Winkel, Bo Gregers ; Jabbari, Reza ; Tfelt-Hansen, Jacob ; Glinge, Charlotte. / Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics. I: European Heart Journal: Acute Cardiovascular Care. 2024 ; Bind 13, Nr. 3. s. 264–272.

Bibtex

@article{ece88750155541188a782c68b7c12477,

title = "Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics",

abstract = "BACKGROUND AND AIMS: The underlying biological mechanisms of ventricular fibrillation (VF) during acute myocardial infarction are largely unknown. To our knowledge, this is the first proteomic study for this trait, with the aim to identify and characterize proteins that are associated with VF during first ST-elevation myocardial infarction (STEMI).METHODS: We included 230 participants from a Danish ongoing case-control study on patients with first STEMI with VF (case, n = 110) and without VF (control, n = 120) before guided catheter insertion for primary percutaneous coronary intervention. The plasma proteome was investigated using mass spectrometry-based proteomics on plasma samples collected within 24 hours of symptom onset.RESULTS: In 229 STEMI patients (72% men, median age 62 years (interquartile range (IQR): 54-70)), a median of 257 proteins (IQR: 244-281) were quantified per patient. A total of 26 proteins were associated with VF, these proteins were involved in several biological processes including blood coagulation, hemostasis, and immunity. After correcting for multiple testing, two up-regulated proteins remained significantly associated with VF, actin beta-like 2 (ACTBL2, fold-change (FC) 2.25, p < 0.001, q = 0.023) and coagulation factor XIII-A (F13A1, FC 1.48, p < 0.001, q = 0.023). None of the proteins were correlated with anterior infarct location.CONCLUSION: VF due to first STEMI was significantly associated with two up-regulated proteins (ACTBL2 and F13A1), suggesting that they may represent novel underlying molecular VF mechanisms. Further research is needed to determine whether these proteins are predictive biomarkers or acute phase response proteins to VF during acute ischemia.",

author = "Stampe, {Niels Kj{\ae}r} and Ottenheijm, {Maud Eline} and Lylia Drici and Albrechtsen, {Nicolai J. Wewer} and Nielsen, {Annelaura Bach} and Christina Christoffersen and Warming, {Peder Emil} and Thomas Engstr{\o}m and Winkel, {Bo Gregers} and Reza Jabbari and Jacob Tfelt-Hansen and Charlotte Glinge",

note = "{\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",

year = "2024",

doi = "10.1093/ehjacc/zuad125",

language = "English",

volume = "13",

pages = "264–272",

journal = "European Heart Journal: Acute Cardiovascular Care",

issn = "2048-8726",

publisher = "SAGE Publications",

number = "3",

}

RIS

TY - JOUR

T1 - Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics

AU - Stampe, Niels Kjær

AU - Ottenheijm, Maud Eline

AU - Drici, Lylia

AU - Albrechtsen, Nicolai J. Wewer

AU - Nielsen, Annelaura Bach

AU - Christoffersen, Christina

AU - Warming, Peder Emil

AU - Engstrøm, Thomas

AU - Winkel, Bo Gregers

AU - Jabbari, Reza

AU - Tfelt-Hansen, Jacob

AU - Glinge, Charlotte

PY - 2024

Y1 - 2024

N2 - BACKGROUND AND AIMS: The underlying biological mechanisms of ventricular fibrillation (VF) during acute myocardial infarction are largely unknown. To our knowledge, this is the first proteomic study for this trait, with the aim to identify and characterize proteins that are associated with VF during first ST-elevation myocardial infarction (STEMI).METHODS: We included 230 participants from a Danish ongoing case-control study on patients with first STEMI with VF (case, n = 110) and without VF (control, n = 120) before guided catheter insertion for primary percutaneous coronary intervention. The plasma proteome was investigated using mass spectrometry-based proteomics on plasma samples collected within 24 hours of symptom onset.RESULTS: In 229 STEMI patients (72% men, median age 62 years (interquartile range (IQR): 54-70)), a median of 257 proteins (IQR: 244-281) were quantified per patient. A total of 26 proteins were associated with VF, these proteins were involved in several biological processes including blood coagulation, hemostasis, and immunity. After correcting for multiple testing, two up-regulated proteins remained significantly associated with VF, actin beta-like 2 (ACTBL2, fold-change (FC) 2.25, p < 0.001, q = 0.023) and coagulation factor XIII-A (F13A1, FC 1.48, p < 0.001, q = 0.023). None of the proteins were correlated with anterior infarct location.CONCLUSION: VF due to first STEMI was significantly associated with two up-regulated proteins (ACTBL2 and F13A1), suggesting that they may represent novel underlying molecular VF mechanisms. Further research is needed to determine whether these proteins are predictive biomarkers or acute phase response proteins to VF during acute ischemia.

AB - BACKGROUND AND AIMS: The underlying biological mechanisms of ventricular fibrillation (VF) during acute myocardial infarction are largely unknown. To our knowledge, this is the first proteomic study for this trait, with the aim to identify and characterize proteins that are associated with VF during first ST-elevation myocardial infarction (STEMI).METHODS: We included 230 participants from a Danish ongoing case-control study on patients with first STEMI with VF (case, n = 110) and without VF (control, n = 120) before guided catheter insertion for primary percutaneous coronary intervention. The plasma proteome was investigated using mass spectrometry-based proteomics on plasma samples collected within 24 hours of symptom onset.RESULTS: In 229 STEMI patients (72% men, median age 62 years (interquartile range (IQR): 54-70)), a median of 257 proteins (IQR: 244-281) were quantified per patient. A total of 26 proteins were associated with VF, these proteins were involved in several biological processes including blood coagulation, hemostasis, and immunity. After correcting for multiple testing, two up-regulated proteins remained significantly associated with VF, actin beta-like 2 (ACTBL2, fold-change (FC) 2.25, p < 0.001, q = 0.023) and coagulation factor XIII-A (F13A1, FC 1.48, p < 0.001, q = 0.023). None of the proteins were correlated with anterior infarct location.CONCLUSION: VF due to first STEMI was significantly associated with two up-regulated proteins (ACTBL2 and F13A1), suggesting that they may represent novel underlying molecular VF mechanisms. Further research is needed to determine whether these proteins are predictive biomarkers or acute phase response proteins to VF during acute ischemia.

U2 - 10.1093/ehjacc/zuad125

DO - 10.1093/ehjacc/zuad125

M3 - Journal article

C2 - 37811694

VL - 13

SP - 264

EP - 272

JO - European Heart Journal: Acute Cardiovascular Care

JF - European Heart Journal: Acute Cardiovascular Care

SN - 2048-8726

IS - 3

ER -

ID: 378131317