Disability in progressive MS is associated with T2 lesion changes
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Disability in progressive MS is associated with T2 lesion changes. / Ammitzbøll, C; Dyrby, T B; Lyksborg, M; Schreiber, K; Ratzer, R; Romme Christensen, J; Iversen, P; Magyari, M; Garde, E; Sørensen, P S; Siebner, H R; Sellebjerg, F.
I: Multiple Sclerosis and Related Disorders, Bind 20, 2018, s. 73-77.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Disability in progressive MS is associated with T2 lesion changes
AU - Ammitzbøll, C
AU - Dyrby, T B
AU - Lyksborg, M
AU - Schreiber, K
AU - Ratzer, R
AU - Romme Christensen, J
AU - Iversen, P
AU - Magyari, M
AU - Garde, E
AU - Sørensen, P S
AU - Siebner, H R
AU - Sellebjerg, F
N1 - Copyright © 2017 Elsevier B.V. All rights reserved.
PY - 2018
Y1 - 2018
N2 - BACKGROUND: Progressive multiple sclerosis (MS) is characterised by diffuse changes on brain magnetic resonance imaging (MRI), which complicates the use of MRI as a diagnostic and prognostic marker. The relationship between MRI measures (conventional and non-conventional) and clinical disability in progressive MS therefore warrants further investigation.OBJECTIVE: To investigate the relationship between clinical disability and MRI measures in patients with progressive MS.METHODS: Data from 93 primary and secondary progressive MS patients who had participated in 3 phase 2 clinical trials were included in this cross-sectional study. From 3T MRI baseline scans we calculated total T2 lesion volume and analysed magnetisation transfer ratio (MTR) and the diffusion tensor imaging indices fractional anisotropy (FA) and mean diffusivity (MD) in T2 lesions, normal-appearing white matter (NAWM) and cortical grey matter. Disability was assessed by the Expanded Disability Status Scale (EDSS) and the MS functional composite.RESULTS: T2 lesion volume was associated with impairment by all clinical measures. MD and MTR in T2 lesions were significantly related to disability, and lower FA values correlated with worse hand function in NAWM. In multivariable analyses, increasing clinical disability was independently correlated with increasing T2 lesion volumes and MTR in T2 lesions.CONCLUSION: In progressive MS, clinical disability is related to lesion volume and microstructure.
AB - BACKGROUND: Progressive multiple sclerosis (MS) is characterised by diffuse changes on brain magnetic resonance imaging (MRI), which complicates the use of MRI as a diagnostic and prognostic marker. The relationship between MRI measures (conventional and non-conventional) and clinical disability in progressive MS therefore warrants further investigation.OBJECTIVE: To investigate the relationship between clinical disability and MRI measures in patients with progressive MS.METHODS: Data from 93 primary and secondary progressive MS patients who had participated in 3 phase 2 clinical trials were included in this cross-sectional study. From 3T MRI baseline scans we calculated total T2 lesion volume and analysed magnetisation transfer ratio (MTR) and the diffusion tensor imaging indices fractional anisotropy (FA) and mean diffusivity (MD) in T2 lesions, normal-appearing white matter (NAWM) and cortical grey matter. Disability was assessed by the Expanded Disability Status Scale (EDSS) and the MS functional composite.RESULTS: T2 lesion volume was associated with impairment by all clinical measures. MD and MTR in T2 lesions were significantly related to disability, and lower FA values correlated with worse hand function in NAWM. In multivariable analyses, increasing clinical disability was independently correlated with increasing T2 lesion volumes and MTR in T2 lesions.CONCLUSION: In progressive MS, clinical disability is related to lesion volume and microstructure.
KW - Brain/diagnostic imaging
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Diffusion Tensor Imaging
KW - Disability Evaluation
KW - Female
KW - Gray Matter/diagnostic imaging
KW - Humans
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis, Chronic Progressive/diagnostic imaging
KW - White Matter/diagnostic imaging
U2 - 10.1016/j.msard.2017.12.010
DO - 10.1016/j.msard.2017.12.010
M3 - Journal article
C2 - 29324249
VL - 20
SP - 73
EP - 77
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
SN - 2211-0348
ER -
ID: 216467333