Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
VAR2CSA is a large polymorphic Plasmodium falciparum protein expressed on infected erythrocytes (IE) that allows their binding in the placenta, thus precipitating placental malaria (PM). The N-terminal part of VAR2CSA that contains the binding site to placental chondroitin sulfate A (CSA) is currently recognized as the most attractive region for vaccine development. An ultimate challenge is to define epitopes in this region that induce a broad cross-reactive adhesion inhibitory antibody response.
Originalsprog | Engelsk |
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Tidsskrift | Vaccine |
Vol/bind | 31 |
Udgave nummer | 41 |
Sider (fra-til) | 4516-22 |
Antal sider | 7 |
ISSN | 0264-410X |
DOI | |
Status | Udgivet - 23 sep. 2013 |
ID: 80641932