Different genetic strategies to generate high amylose starch mutants by engineering the starch biosynthetic pathways

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Different genetic strategies to generate high amylose starch mutants by engineering the starch biosynthetic pathways. / Zhong, Yuyue; Qu, Jian Zhou; Liu, Xingxun; Ding, Li; Liu, Ying; Bertoft, Eric; Petersen, Bent L.; Hamaker, Bruce R.; Hebelstrup, Kim Henrik; Blennow, Andreas.

I: Carbohydrate Polymers, Bind 287, 119327, 2022.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Zhong, Y, Qu, JZ, Liu, X, Ding, L, Liu, Y, Bertoft, E, Petersen, BL, Hamaker, BR, Hebelstrup, KH & Blennow, A 2022, 'Different genetic strategies to generate high amylose starch mutants by engineering the starch biosynthetic pathways', Carbohydrate Polymers, bind 287, 119327. https://doi.org/10.1016/j.carbpol.2022.119327

APA

Zhong, Y., Qu, J. Z., Liu, X., Ding, L., Liu, Y., Bertoft, E., Petersen, B. L., Hamaker, B. R., Hebelstrup, K. H., & Blennow, A. (2022). Different genetic strategies to generate high amylose starch mutants by engineering the starch biosynthetic pathways. Carbohydrate Polymers, 287, [119327]. https://doi.org/10.1016/j.carbpol.2022.119327

Vancouver

Zhong Y, Qu JZ, Liu X, Ding L, Liu Y, Bertoft E o.a. Different genetic strategies to generate high amylose starch mutants by engineering the starch biosynthetic pathways. Carbohydrate Polymers. 2022;287. 119327. https://doi.org/10.1016/j.carbpol.2022.119327

Author

Zhong, Yuyue ; Qu, Jian Zhou ; Liu, Xingxun ; Ding, Li ; Liu, Ying ; Bertoft, Eric ; Petersen, Bent L. ; Hamaker, Bruce R. ; Hebelstrup, Kim Henrik ; Blennow, Andreas. / Different genetic strategies to generate high amylose starch mutants by engineering the starch biosynthetic pathways. I: Carbohydrate Polymers. 2022 ; Bind 287.

Bibtex

@article{b3d9482a121340f1af42fcba64775f5d,
title = "Different genetic strategies to generate high amylose starch mutants by engineering the starch biosynthetic pathways",
abstract = "This review systematically documents the major different strategies of generating high-amylose (HAS) starch mutants aiming at providing high resistant starch, by engineering the starch biosynthesis metabolic pathways. We identify three main strategies based on a new representation of the starch structure: {\textquoteleft}the building block backbone model{\textquoteright}: i) suppression of starch synthases for reduction of amylopectin (AP) side-chains; ii) suppression of starch branching enzymes (SBEs) for production of AM-like materials; and iii) suppression of debranching enzymes to restrain the transformation from over-branched pre-AP to more ordered AP. From a biosynthetic perspective, AM generated through the second strategy can be classified into two types: i) normal AM synthesized mainly by regular expression of granule-bound starch synthases, and ii) modified linear AP chains (AM-like material) synthesized by starch synthases due to the suppression of starch branching enzymes. The application of new breeding technologies, especially CRISPR, in the breeding of HAS crops is also reviewed.",
keywords = "Amylose-like material, Backbone model, Biosynthesis, High-amylose starch, Starch branching enzyme",
author = "Yuyue Zhong and Qu, {Jian Zhou} and Xingxun Liu and Li Ding and Ying Liu and Eric Bertoft and Petersen, {Bent L.} and Hamaker, {Bruce R.} and Hebelstrup, {Kim Henrik} and Andreas Blennow",
note = "Publisher Copyright: {\textcopyright} 2022",
year = "2022",
doi = "10.1016/j.carbpol.2022.119327",
language = "English",
volume = "287",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Different genetic strategies to generate high amylose starch mutants by engineering the starch biosynthetic pathways

AU - Zhong, Yuyue

AU - Qu, Jian Zhou

AU - Liu, Xingxun

AU - Ding, Li

AU - Liu, Ying

AU - Bertoft, Eric

AU - Petersen, Bent L.

AU - Hamaker, Bruce R.

AU - Hebelstrup, Kim Henrik

AU - Blennow, Andreas

N1 - Publisher Copyright: © 2022

PY - 2022

Y1 - 2022

N2 - This review systematically documents the major different strategies of generating high-amylose (HAS) starch mutants aiming at providing high resistant starch, by engineering the starch biosynthesis metabolic pathways. We identify three main strategies based on a new representation of the starch structure: ‘the building block backbone model’: i) suppression of starch synthases for reduction of amylopectin (AP) side-chains; ii) suppression of starch branching enzymes (SBEs) for production of AM-like materials; and iii) suppression of debranching enzymes to restrain the transformation from over-branched pre-AP to more ordered AP. From a biosynthetic perspective, AM generated through the second strategy can be classified into two types: i) normal AM synthesized mainly by regular expression of granule-bound starch synthases, and ii) modified linear AP chains (AM-like material) synthesized by starch synthases due to the suppression of starch branching enzymes. The application of new breeding technologies, especially CRISPR, in the breeding of HAS crops is also reviewed.

AB - This review systematically documents the major different strategies of generating high-amylose (HAS) starch mutants aiming at providing high resistant starch, by engineering the starch biosynthesis metabolic pathways. We identify three main strategies based on a new representation of the starch structure: ‘the building block backbone model’: i) suppression of starch synthases for reduction of amylopectin (AP) side-chains; ii) suppression of starch branching enzymes (SBEs) for production of AM-like materials; and iii) suppression of debranching enzymes to restrain the transformation from over-branched pre-AP to more ordered AP. From a biosynthetic perspective, AM generated through the second strategy can be classified into two types: i) normal AM synthesized mainly by regular expression of granule-bound starch synthases, and ii) modified linear AP chains (AM-like material) synthesized by starch synthases due to the suppression of starch branching enzymes. The application of new breeding technologies, especially CRISPR, in the breeding of HAS crops is also reviewed.

KW - Amylose-like material

KW - Backbone model

KW - Biosynthesis

KW - High-amylose starch

KW - Starch branching enzyme

U2 - 10.1016/j.carbpol.2022.119327

DO - 10.1016/j.carbpol.2022.119327

M3 - Review

C2 - 35422293

AN - SCOPUS:85126285738

VL - 287

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

M1 - 119327

ER -

ID: 310145035