Diet-microbiota crosstalk and immunity to helminth infection
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Helminths are large multicellular parasites responsible for widespread chronic disease in humans and animals. Intestinal helminths live in close proximity with the host gut microbiota and mucosal immune network, resulting in reciprocal interactions that closely influence the course of infections. Diet composition may strongly regulate gut microbiota composition and intestinal immune function and therefore may play a key role in modulating anti-helminth immune responses. Characterizing the multitude of interactions that exist between different dietary components (e.g., dietary fibres), immune cells, and the microbiota, may shed new light on regulation of helminth-specific immunity. This review focuses on the current knowledge of how metabolism of dietary components shapes immune response during helminth infection, and how this information may be potentially harnessed to design new therapeutics to manage parasitic infections and associated diseases.
Originalsprog | Engelsk |
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Artikelnummer | 12965 |
Tidsskrift | Parasite Immunology |
Vol/bind | 45 |
Udgave nummer | 4 |
ISSN | 0141-9838 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
We acknowledge financial support from the Novo Nordisk Foundation (Grant 0052422) and Independent Research Fund Denmark (Grant 7026‐0094B). Figures were created using BioRender.com .
Funding Information:
Danmarks Frie Forskningsfond, Grant/Award Number: 7026‐0094B; Novo Nordisk Fonden, Grant/Award Number: 0052422; Novo Nordisk Foundation; Independent Research Fund Denmark Funding information
Publisher Copyright:
© 2022 The Authors. Parasite Immunology published by John Wiley & Sons Ltd.
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