Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients

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Standard

Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients. / Kurtzhals, J A; Hey, A S; Jardim, A; Kemp, M; Schaefer, K U; Odera, E O; Christensen, C B; Githure, J I; Olafson, R W; Theander, T G.

I: Clinical and Experimental Immunology, Bind 96, Nr. 3, 1994, s. 416-21.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kurtzhals, JA, Hey, AS, Jardim, A, Kemp, M, Schaefer, KU, Odera, EO, Christensen, CB, Githure, JI, Olafson, RW & Theander, TG 1994, 'Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients', Clinical and Experimental Immunology, bind 96, nr. 3, s. 416-21.

APA

Kurtzhals, J. A., Hey, A. S., Jardim, A., Kemp, M., Schaefer, K. U., Odera, E. O., Christensen, C. B., Githure, J. I., Olafson, R. W., & Theander, T. G. (1994). Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients. Clinical and Experimental Immunology, 96(3), 416-21.

Vancouver

Kurtzhals JA, Hey AS, Jardim A, Kemp M, Schaefer KU, Odera EO o.a. Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients. Clinical and Experimental Immunology. 1994;96(3):416-21.

Author

Kurtzhals, J A ; Hey, A S ; Jardim, A ; Kemp, M ; Schaefer, K U ; Odera, E O ; Christensen, C B ; Githure, J I ; Olafson, R W ; Theander, T G. / Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients. I: Clinical and Experimental Immunology. 1994 ; Bind 96, Nr. 3. s. 416-21.

Bibtex

@article{8c7e1210a0da11dd86a6000ea68e967b,
title = "Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients",
abstract = "The T cell response to different Leishmania donovani antigens was investigated using peripheral blood mononuclear cells (PBMC) from Kenyans cured of visceral leishmaniasis and non-exposed Danes. Crude promastigote and amastigote antigens both induced proliferation and interferon-gamma (IFN-gamma) production in PBMC from cured patients, while cells from non-exposed donors gave weak responses. A similar pattern was induced by lipophosphoglycan-associated protein (LPGAP). By contrast, the major surface protease of Leishmania, gp63, induced only a weak proliferative response without IFN-gamma production in five of 17 samples from cured patients. Four of the five responding cultures produced IL-4, i.e. the response to this antigen was of the Th2 type. Furthermore, sera from acutely ill visceral leishmaniasis patients contained high levels of IgG antibodies to gp63. The Th2-like response to gp63 in patients cured of visceral leishmaniasis differs from the Th1-like response to the same antigen observed in patients cured of cutaneous leishmaniasis.",
author = "Kurtzhals, {J A} and Hey, {A S} and A Jardim and M Kemp and Schaefer, {K U} and Odera, {E O} and Christensen, {C B} and Githure, {J I} and Olafson, {R W} and Theander, {T G}",
note = "Keywords: Animals; Antibodies, Protozoan; Antigens, Protozoan; Glycosphingolipids; Humans; Interferon Type II; Interleukin-4; Leishmania donovani; Leishmaniasis, Visceral; Lymphocyte Activation; Metalloendopeptidases; Protozoan Proteins; T-Lymphocyte Subsets; T-Lymphocytes; T-Lymphocytes, Helper-Inducer",
year = "1994",
language = "English",
volume = "96",
pages = "416--21",
journal = "Clinical and Experimental Immunology, Supplement",
issn = "0964-2536",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients

AU - Kurtzhals, J A

AU - Hey, A S

AU - Jardim, A

AU - Kemp, M

AU - Schaefer, K U

AU - Odera, E O

AU - Christensen, C B

AU - Githure, J I

AU - Olafson, R W

AU - Theander, T G

N1 - Keywords: Animals; Antibodies, Protozoan; Antigens, Protozoan; Glycosphingolipids; Humans; Interferon Type II; Interleukin-4; Leishmania donovani; Leishmaniasis, Visceral; Lymphocyte Activation; Metalloendopeptidases; Protozoan Proteins; T-Lymphocyte Subsets; T-Lymphocytes; T-Lymphocytes, Helper-Inducer

PY - 1994

Y1 - 1994

N2 - The T cell response to different Leishmania donovani antigens was investigated using peripheral blood mononuclear cells (PBMC) from Kenyans cured of visceral leishmaniasis and non-exposed Danes. Crude promastigote and amastigote antigens both induced proliferation and interferon-gamma (IFN-gamma) production in PBMC from cured patients, while cells from non-exposed donors gave weak responses. A similar pattern was induced by lipophosphoglycan-associated protein (LPGAP). By contrast, the major surface protease of Leishmania, gp63, induced only a weak proliferative response without IFN-gamma production in five of 17 samples from cured patients. Four of the five responding cultures produced IL-4, i.e. the response to this antigen was of the Th2 type. Furthermore, sera from acutely ill visceral leishmaniasis patients contained high levels of IgG antibodies to gp63. The Th2-like response to gp63 in patients cured of visceral leishmaniasis differs from the Th1-like response to the same antigen observed in patients cured of cutaneous leishmaniasis.

AB - The T cell response to different Leishmania donovani antigens was investigated using peripheral blood mononuclear cells (PBMC) from Kenyans cured of visceral leishmaniasis and non-exposed Danes. Crude promastigote and amastigote antigens both induced proliferation and interferon-gamma (IFN-gamma) production in PBMC from cured patients, while cells from non-exposed donors gave weak responses. A similar pattern was induced by lipophosphoglycan-associated protein (LPGAP). By contrast, the major surface protease of Leishmania, gp63, induced only a weak proliferative response without IFN-gamma production in five of 17 samples from cured patients. Four of the five responding cultures produced IL-4, i.e. the response to this antigen was of the Th2 type. Furthermore, sera from acutely ill visceral leishmaniasis patients contained high levels of IgG antibodies to gp63. The Th2-like response to gp63 in patients cured of visceral leishmaniasis differs from the Th1-like response to the same antigen observed in patients cured of cutaneous leishmaniasis.

M3 - Journal article

C2 - 8004810

VL - 96

SP - 416

EP - 421

JO - Clinical and Experimental Immunology, Supplement

JF - Clinical and Experimental Immunology, Supplement

SN - 0964-2536

IS - 3

ER -

ID: 6766599