Diarrhoea in neonatal piglets: A case control study on microbiological findings
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Diarrhoea in neonatal piglets : A case control study on microbiological findings. / Kongsted, Hanne; Pedersen, Karl; Hjulsager, Charlotte Kristiane; Larsen, Lars Erik; Pedersen, Ken Steen; Jorsal, Sven Erik; Bækbo, Poul.
I: Porcine Health Management, Bind 4, Nr. 1, 17, 03.09.2018.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Diarrhoea in neonatal piglets
T2 - A case control study on microbiological findings
AU - Kongsted, Hanne
AU - Pedersen, Karl
AU - Hjulsager, Charlotte Kristiane
AU - Larsen, Lars Erik
AU - Pedersen, Ken Steen
AU - Jorsal, Sven Erik
AU - Bækbo, Poul
PY - 2018/9/3
Y1 - 2018/9/3
N2 - Background: Many factors can influence the occurrence of neonatal diarrhoea in piglets. Currently, well-known pathogens such as enterotoxigenic Escherichia coli and Clostridium perfringens type C appear to play a minor role in development of disease. Other infectious pathogens may be involved. In this study, we aimed to investigate the presence of selected infectious pathogens in neonatal piglets with clinical and pathological signs of enteric disease. The association between rotavirus A, Enterococcus hirae, Clostridium difficile and Clostridium perfringens type A/C and diarrhoea was investigated in a case control study on piglet level. The possible role of E. coli virulence factors was investigated in a multistep-procedure using herd-pools of E.coli isolates to screen for their presence. Results: Rotavirus A was detected more often in cases (25%) than in controls (6%) (P<0.001). The detection rate of Enterococcus hirae, Clostridium difficile and C. perfringens type A positive for beta2 genes was the same in the two groups of piglets. C. perfringens type C was not detected in the study. Investigations on E. coli virulence factors showed a high prevalence of EAST1 toxin genes (55% of tested case piglets were positive) and AIDA-1 adhesin genes (63% of toxin positive case piglets were positive) in case piglets. Conclusions: Detection of rotavirus A was statistically significantly associated with neonatal piglet diarrhoea. An aetiologic role of E. coli carrying virulence factors EAST1 and AIDA-1 needs further investigation as the study points out these two factors as possible causative factors in neonatal diarrhoea. Detection of E.hirae, C.difficile and C. perfringens type A carrying beta 2 genes was not associated with neonatal piglet diarrhoea. However, the study suggested that massive overgrowth by E. hirae could be part of the pathogenesis in some cases of neonatal diarrhoea.
AB - Background: Many factors can influence the occurrence of neonatal diarrhoea in piglets. Currently, well-known pathogens such as enterotoxigenic Escherichia coli and Clostridium perfringens type C appear to play a minor role in development of disease. Other infectious pathogens may be involved. In this study, we aimed to investigate the presence of selected infectious pathogens in neonatal piglets with clinical and pathological signs of enteric disease. The association between rotavirus A, Enterococcus hirae, Clostridium difficile and Clostridium perfringens type A/C and diarrhoea was investigated in a case control study on piglet level. The possible role of E. coli virulence factors was investigated in a multistep-procedure using herd-pools of E.coli isolates to screen for their presence. Results: Rotavirus A was detected more often in cases (25%) than in controls (6%) (P<0.001). The detection rate of Enterococcus hirae, Clostridium difficile and C. perfringens type A positive for beta2 genes was the same in the two groups of piglets. C. perfringens type C was not detected in the study. Investigations on E. coli virulence factors showed a high prevalence of EAST1 toxin genes (55% of tested case piglets were positive) and AIDA-1 adhesin genes (63% of toxin positive case piglets were positive) in case piglets. Conclusions: Detection of rotavirus A was statistically significantly associated with neonatal piglet diarrhoea. An aetiologic role of E. coli carrying virulence factors EAST1 and AIDA-1 needs further investigation as the study points out these two factors as possible causative factors in neonatal diarrhoea. Detection of E.hirae, C.difficile and C. perfringens type A carrying beta 2 genes was not associated with neonatal piglet diarrhoea. However, the study suggested that massive overgrowth by E. hirae could be part of the pathogenesis in some cases of neonatal diarrhoea.
KW - AIDA-1
KW - Beta 2
KW - C. difficile
KW - C. perfringens type a
KW - E. coli virulence factors
KW - EAST1
KW - Enterococcus hirae
KW - Neonatal diarrhoea
KW - Piglets
KW - Rotavirus a
U2 - 10.1186/s40813-018-0094-5
DO - 10.1186/s40813-018-0094-5
M3 - Journal article
AN - SCOPUS:85057101938
VL - 4
JO - Porcine Health Management
JF - Porcine Health Management
SN - 2055-5660
IS - 1
M1 - 17
ER -
ID: 247393369