Development of visual attention from age 7 to age 12 in children with familial high risk for schizophrenia or bipolar disorder
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Development of visual attention from age 7 to age 12 in children with familial high risk for schizophrenia or bipolar disorder. / Ver Loren van Themaat, Anna Hester; Hemager, Nicoline; Korsgaard Johnsen, Line; Klee Burton, Birgitte; Ellersgaard, Ditte; Christiani, Camilla; Brandt, Julie; Gregersen, Maja; Falkenberg Krantz, Mette; Søborg Spang, Katrine; Søndergaard, Anne; Møllegaard Jepsen, Jens Richardt; Elgaard Thorup, Anne Amalie; Siebner, Hartwig Roman; Plessen, Kerstin Jessica; Nordentoft, Merete; Vangkilde, Signe.
I: Schizophrenia Research, Bind 228, 2021, s. 327-335.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Development of visual attention from age 7 to age 12 in children with familial high risk for schizophrenia or bipolar disorder
AU - Ver Loren van Themaat, Anna Hester
AU - Hemager, Nicoline
AU - Korsgaard Johnsen, Line
AU - Klee Burton, Birgitte
AU - Ellersgaard, Ditte
AU - Christiani, Camilla
AU - Brandt, Julie
AU - Gregersen, Maja
AU - Falkenberg Krantz, Mette
AU - Søborg Spang, Katrine
AU - Søndergaard, Anne
AU - Møllegaard Jepsen, Jens Richardt
AU - Elgaard Thorup, Anne Amalie
AU - Siebner, Hartwig Roman
AU - Plessen, Kerstin Jessica
AU - Nordentoft, Merete
AU - Vangkilde, Signe
PY - 2021
Y1 - 2021
N2 - Background: Children with familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) are at increased risk of developing similar disorders and show cognitive deficits during childhood. The aim of this paper is to investigate visual attention and its developmental trajectories in children with FHR-SZ and with FHR-BP to increase our knowledge about potential cognitive endophenotypes of these two disorders. Methods: We compared the performance of 89 children with FHR-SZ (N = 32), FHR-BP (N = 22), and population-based controls (PBC, N = 35) at age 7 to that at age 12 as well as including 133 12-year-old children with FHR-SZ (N = 50), FHR-BP (N = 43) and PBC (N = 40) to investigate visual attention, as part of the Danish High Risk and Resilience Study. We used the TVA-based whole report paradigm, based on the Bundesen's Theory of Visual Attention (TVA) to investigate visual attention. Results: Children with FHR-SZ that showed deficits in visual processing speed at age 7 improved to a level that was not significantly different from controls at age 12. All children improved over time. We found no attentional deficits in FHR children at age 12. Conclusions: On visual attention, children with FHR-SZ did not show developmental deficits or lags and, together with children with FHR-BP, they develop similarly to control children between age 7 to age 12. This emphasizes the potential of beneficial neuroplastic changes in cognitive deficits found at younger ages in children with FHR-SZ. It also highlights the importance of identifying and characterizing cognitive developmental trajectories of high-risk children and provides hope that visual attention may develop appropriately in these groups.
AB - Background: Children with familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) are at increased risk of developing similar disorders and show cognitive deficits during childhood. The aim of this paper is to investigate visual attention and its developmental trajectories in children with FHR-SZ and with FHR-BP to increase our knowledge about potential cognitive endophenotypes of these two disorders. Methods: We compared the performance of 89 children with FHR-SZ (N = 32), FHR-BP (N = 22), and population-based controls (PBC, N = 35) at age 7 to that at age 12 as well as including 133 12-year-old children with FHR-SZ (N = 50), FHR-BP (N = 43) and PBC (N = 40) to investigate visual attention, as part of the Danish High Risk and Resilience Study. We used the TVA-based whole report paradigm, based on the Bundesen's Theory of Visual Attention (TVA) to investigate visual attention. Results: Children with FHR-SZ that showed deficits in visual processing speed at age 7 improved to a level that was not significantly different from controls at age 12. All children improved over time. We found no attentional deficits in FHR children at age 12. Conclusions: On visual attention, children with FHR-SZ did not show developmental deficits or lags and, together with children with FHR-BP, they develop similarly to control children between age 7 to age 12. This emphasizes the potential of beneficial neuroplastic changes in cognitive deficits found at younger ages in children with FHR-SZ. It also highlights the importance of identifying and characterizing cognitive developmental trajectories of high-risk children and provides hope that visual attention may develop appropriately in these groups.
KW - Bipolar disorder
KW - Cognitive trajectory
KW - Familial high-risk
KW - Neurodevelopment
KW - Schizophrenia
KW - Visual attention
U2 - 10.1016/j.schres.2020.12.031
DO - 10.1016/j.schres.2020.12.031
M3 - Journal article
C2 - 33540144
AN - SCOPUS:85100312737
VL - 228
SP - 327
EP - 335
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
ER -
ID: 256939079