Development of a Divergent Route to Erythrina Alkaloids

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) - one of the most prominent members of this intriguing family of natural products. 1 Introduction 2 Synthetic Strategy 2.1 First Generation 2.2 Second Generation 2.3 Third Generation 2.3.1 Radical Endgame 2.3.2 Completion of the Total Synthesis 3 Conclusion.

OriginalsprogEngelsk
Artikelnummerst-2019-a0679-a
TidsskriftSynlett
Vol/bind31
Udgave nummer4
Sider (fra-til)327-333
Antal sider7
ISSN0936-5214
DOI
StatusUdgivet - 3 mar. 2020

ID: 239730152