Development of a Divergent Route to Erythrina Alkaloids
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Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) - one of the most prominent members of this intriguing family of natural products. 1 Introduction 2 Synthetic Strategy 2.1 First Generation 2.2 Second Generation 2.3 Third Generation 2.3.1 Radical Endgame 2.3.2 Completion of the Total Synthesis 3 Conclusion.
Originalsprog | Engelsk |
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Artikelnummer | st-2019-a0679-a |
Tidsskrift | Synlett |
Vol/bind | 31 |
Udgave nummer | 4 |
Sider (fra-til) | 327-333 |
Antal sider | 7 |
ISSN | 0936-5214 |
DOI | |
Status | Udgivet - 3 mar. 2020 |
ID: 239730152