Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Modulation of DNA base excision repair (BER) has the potential to enhance response to chemotherapy and improve outcomes in tumours such as melanoma and glioma. APE1, a critical protein in BER that processes potentially cytotoxic abasic sites (AP sites), is a promising new target in cancer. In the current study, we aimed to develop small molecule inhibitors of APE1 for cancer therapy.
Originalsprog | Engelsk |
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Tidsskrift | British Journal of Cancer Management |
Vol/bind | 104 |
Udgave nummer | 4 |
Sider (fra-til) | 653-63 |
Antal sider | 11 |
ISSN | 1744-3865 |
DOI | |
Status | Udgivet - 15 feb. 2011 |
ID: 33489785