Dense distributed processing in a hindlimb scratch motor network
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
In reduced preparations, hindlimb movements can be generated by a minimal network of neurons in the limb innervating spinal segments. The network of neurons that generates real movements is less well delineated. In an ex vivo carapace-spinal cord preparation from adult turtles (Trachemys scripta elegans), we show that ventral horn interneurons in mid-thoracic spinal segments are functionally integrated in the hindlimb scratch network. First, mid-thoracic interneurons receive intense synaptic input during scratching and behave like neurons in the hindlimb enlargement. Second, some mid-thoracic interneurons activated during scratching project descending axons toward the hindlimb enlargement. Third, elimination of mid-thoracic segments leads to a weakening of scratch rhythmicity. We conclude that densely innervated interneurons in mid-thoracic segments contribute to hindlimb scratching and may be part of a distributed motor network that secures motor coherence.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Neuroscience |
Vol/bind | 34 |
Udgave nummer | 32 |
Sider (fra-til) | 10756-10764 |
Antal sider | 8 |
ISSN | 0270-6474 |
DOI | |
Status | Udgivet - 6 aug. 2014 |
ID: 138803434