Delineating papillary dermis around basal cell carcinomas by high and ultrahigh resolution optical coherence tomography: A pilot study
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Delineating papillary dermis around basal cell carcinomas by high and ultrahigh resolution optical coherence tomography : A pilot study. / Møller Israelsen, Niels; Mogensen, Mette; Jensen, Mikkel; Haedersdal, Merete; Bang, Ole.
I: journal of biophotonics, Bind 14, Nr. 11, e202100083, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Delineating papillary dermis around basal cell carcinomas by high and ultrahigh resolution optical coherence tomography
T2 - A pilot study
AU - Møller Israelsen, Niels
AU - Mogensen, Mette
AU - Jensen, Mikkel
AU - Haedersdal, Merete
AU - Bang, Ole
N1 - Funding Information: We acknowledge support from Innovation Fund Denmark under the project J. No. 4107‐00011A (ShapeOCT), Vissing Foundation, Denmark and the Research Foundation of Bispebjerg and Frederiksberg Hospital financing part of Mette Mogensen's salary. Publisher Copyright: © 2021 Wiley-VCH GmbH
PY - 2021
Y1 - 2021
N2 - Bedside diagnosis of skin cancer remains a challenging task. The real-time noninvasive technology of optical coherence tomography (OCT) masters a high diagnostic accuracy in basal cell carcinoma (BCC) but a lower specificity in recognizing imitators and other carcinomas. We investigate the delicate signal of papillary dermis using an in-house developed ultrahigh resolution OCT (UHR-OCT) system with shadow compensation and a commercial multi-focus high resolution OCT (HR-OCT) system for clinical BCC imaging. We find that the HR-OCT system struggled to resolve the dark band signal of papillary dermis where the UHR-OCT located this in all cases and detected changes in signal width. UHR-OCT is able to monitor extension and position of papillary dermis suggesting a novel feature for delineating superficial BCCs in pursuit of a fast accurate diagnosis. Comprehensive studies involving more patients are imperative in order to corroborate results.
AB - Bedside diagnosis of skin cancer remains a challenging task. The real-time noninvasive technology of optical coherence tomography (OCT) masters a high diagnostic accuracy in basal cell carcinoma (BCC) but a lower specificity in recognizing imitators and other carcinomas. We investigate the delicate signal of papillary dermis using an in-house developed ultrahigh resolution OCT (UHR-OCT) system with shadow compensation and a commercial multi-focus high resolution OCT (HR-OCT) system for clinical BCC imaging. We find that the HR-OCT system struggled to resolve the dark band signal of papillary dermis where the UHR-OCT located this in all cases and detected changes in signal width. UHR-OCT is able to monitor extension and position of papillary dermis suggesting a novel feature for delineating superficial BCCs in pursuit of a fast accurate diagnosis. Comprehensive studies involving more patients are imperative in order to corroborate results.
KW - angiography
KW - basal cell carcinoma
KW - BCC
KW - OCT
KW - optical coherence tomography
KW - papillary dermis
KW - ultrahigh resolution
KW - upper dermis
U2 - 10.1002/jbio.202100083
DO - 10.1002/jbio.202100083
M3 - Journal article
C2 - 34245133
AN - SCOPUS:85111723227
VL - 14
JO - Journal of Biophotonics
JF - Journal of Biophotonics
SN - 1864-063X
IS - 11
M1 - e202100083
ER -
ID: 301620701