TY - JOUR

T1 - Delineating papillary dermis around basal cell carcinomas by high and ultrahigh resolution optical coherence tomography

T2 - A pilot study

AU - Møller Israelsen, Niels

AU - Mogensen, Mette

AU - Jensen, Mikkel

AU - Haedersdal, Merete

AU - Bang, Ole

N1 - Funding Information: We acknowledge support from Innovation Fund Denmark under the project J. No. 4107‐00011A (ShapeOCT), Vissing Foundation, Denmark and the Research Foundation of Bispebjerg and Frederiksberg Hospital financing part of Mette Mogensen's salary. Publisher Copyright: © 2021 Wiley-VCH GmbH

PY - 2021

Y1 - 2021

N2 - Bedside diagnosis of skin cancer remains a challenging task. The real-time noninvasive technology of optical coherence tomography (OCT) masters a high diagnostic accuracy in basal cell carcinoma (BCC) but a lower specificity in recognizing imitators and other carcinomas. We investigate the delicate signal of papillary dermis using an in-house developed ultrahigh resolution OCT (UHR-OCT) system with shadow compensation and a commercial multi-focus high resolution OCT (HR-OCT) system for clinical BCC imaging. We find that the HR-OCT system struggled to resolve the dark band signal of papillary dermis where the UHR-OCT located this in all cases and detected changes in signal width. UHR-OCT is able to monitor extension and position of papillary dermis suggesting a novel feature for delineating superficial BCCs in pursuit of a fast accurate diagnosis. Comprehensive studies involving more patients are imperative in order to corroborate results.

AB - Bedside diagnosis of skin cancer remains a challenging task. The real-time noninvasive technology of optical coherence tomography (OCT) masters a high diagnostic accuracy in basal cell carcinoma (BCC) but a lower specificity in recognizing imitators and other carcinomas. We investigate the delicate signal of papillary dermis using an in-house developed ultrahigh resolution OCT (UHR-OCT) system with shadow compensation and a commercial multi-focus high resolution OCT (HR-OCT) system for clinical BCC imaging. We find that the HR-OCT system struggled to resolve the dark band signal of papillary dermis where the UHR-OCT located this in all cases and detected changes in signal width. UHR-OCT is able to monitor extension and position of papillary dermis suggesting a novel feature for delineating superficial BCCs in pursuit of a fast accurate diagnosis. Comprehensive studies involving more patients are imperative in order to corroborate results.

KW - angiography

KW - basal cell carcinoma

KW - BCC

KW - OCT

KW - optical coherence tomography

KW - papillary dermis

KW - ultrahigh resolution

KW - upper dermis

U2 - 10.1002/jbio.202100083

DO - 10.1002/jbio.202100083

M3 - Journal article

C2 - 34245133

AN - SCOPUS:85111723227

VL - 14

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 11

M1 - e202100083

ER -