De novo prediction of structured RNAs from genomic sequences

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Standard

De novo prediction of structured RNAs from genomic sequences. / Gorodkin, Jan; Hofacker, Ivo L.; Þórarinsson, Elfar; Yao, Zizhen; Havgaard, Jakob Hull; Ruzzo, Walter L.

I: Trends in Biotechnology, Bind 28, Nr. 1, 2010, s. 9-19.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Gorodkin, J, Hofacker, IL, Þórarinsson, E, Yao, Z, Havgaard, JH & Ruzzo, WL 2010, 'De novo prediction of structured RNAs from genomic sequences', Trends in Biotechnology, bind 28, nr. 1, s. 9-19. https://doi.org/10.1016/j.tibtech.2009.09.006

APA

Gorodkin, J., Hofacker, I. L., Þórarinsson, E., Yao, Z., Havgaard, J. H., & Ruzzo, W. L. (2010). De novo prediction of structured RNAs from genomic sequences. Trends in Biotechnology, 28(1), 9-19. https://doi.org/10.1016/j.tibtech.2009.09.006

Vancouver

Gorodkin J, Hofacker IL, Þórarinsson E, Yao Z, Havgaard JH, Ruzzo WL. De novo prediction of structured RNAs from genomic sequences. Trends in Biotechnology. 2010;28(1):9-19. https://doi.org/10.1016/j.tibtech.2009.09.006

Author

Gorodkin, Jan ; Hofacker, Ivo L. ; Þórarinsson, Elfar ; Yao, Zizhen ; Havgaard, Jakob Hull ; Ruzzo, Walter L. / De novo prediction of structured RNAs from genomic sequences. I: Trends in Biotechnology. 2010 ; Bind 28, Nr. 1. s. 9-19.

Bibtex

@article{e2901ec0275a11df8ed1000ea68e967b,
title = "De novo prediction of structured RNAs from genomic sequences",
abstract = "Growing recognition of the numerous, diverse and important roles played by non-coding RNA in all organisms motivates better elucidation of these cellular components. Comparative genomics is a powerful tool for this task and is arguably preferable to any high-throughput experimental technology currently available, because evolutionary conservation highlights functionally important regions. Conserved secondary structure, rather than primary sequence, is the hallmark of many functionally important RNAs, because compensatory substitutions in base-paired regions preserve structure. Unfortunately, such substitutions also obscure sequence identity and confound alignment algorithms, which complicates analysis greatly. This paper surveys recent computational advances in this difficult arena, which have enabled genome-scale prediction of cross-species conserved RNA elements. These predictions suggest that a wealth of these elements indeed exist",
author = "Jan Gorodkin and Hofacker, {Ivo L.} and Elfar {\TH}{\'o}rarinsson and Zizhen Yao and Havgaard, {Jakob Hull} and Ruzzo, {Walter L.}",
year = "2010",
doi = "10.1016/j.tibtech.2009.09.006",
language = "English",
volume = "28",
pages = "9--19",
journal = "Trends in Biotechnology",
issn = "0167-7799",
publisher = "Elsevier Ltd. * Trends Journals",
number = "1",

}

RIS

TY - JOUR

T1 - De novo prediction of structured RNAs from genomic sequences

AU - Gorodkin, Jan

AU - Hofacker, Ivo L.

AU - Þórarinsson, Elfar

AU - Yao, Zizhen

AU - Havgaard, Jakob Hull

AU - Ruzzo, Walter L.

PY - 2010

Y1 - 2010

N2 - Growing recognition of the numerous, diverse and important roles played by non-coding RNA in all organisms motivates better elucidation of these cellular components. Comparative genomics is a powerful tool for this task and is arguably preferable to any high-throughput experimental technology currently available, because evolutionary conservation highlights functionally important regions. Conserved secondary structure, rather than primary sequence, is the hallmark of many functionally important RNAs, because compensatory substitutions in base-paired regions preserve structure. Unfortunately, such substitutions also obscure sequence identity and confound alignment algorithms, which complicates analysis greatly. This paper surveys recent computational advances in this difficult arena, which have enabled genome-scale prediction of cross-species conserved RNA elements. These predictions suggest that a wealth of these elements indeed exist

AB - Growing recognition of the numerous, diverse and important roles played by non-coding RNA in all organisms motivates better elucidation of these cellular components. Comparative genomics is a powerful tool for this task and is arguably preferable to any high-throughput experimental technology currently available, because evolutionary conservation highlights functionally important regions. Conserved secondary structure, rather than primary sequence, is the hallmark of many functionally important RNAs, because compensatory substitutions in base-paired regions preserve structure. Unfortunately, such substitutions also obscure sequence identity and confound alignment algorithms, which complicates analysis greatly. This paper surveys recent computational advances in this difficult arena, which have enabled genome-scale prediction of cross-species conserved RNA elements. These predictions suggest that a wealth of these elements indeed exist

U2 - 10.1016/j.tibtech.2009.09.006

DO - 10.1016/j.tibtech.2009.09.006

M3 - Journal article

VL - 28

SP - 9

EP - 19

JO - Trends in Biotechnology

JF - Trends in Biotechnology

SN - 0167-7799

IS - 1

ER -

ID: 18363783