Corticosteroids versus clobazam for treatment of children with epileptic encephalopathy with spike-wave activation in sleep (RESCUE ESES): a multicentre randomised controlled trial

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  • RESCUE ESES study group
Epileptic encephalopathy with spike-wave activation in sleep (EE-SWAS) is a rare syndrome associated with cognitive and behavioural regression. On the basis of mostly small observational and retrospective studies, corticosteroids and clobazam are often considered the most effective treatments for this syndrome. We aimed to compare cognitive outcomes of children with EE-SWAS 6 months after starting treatment with either corticosteroids or clobazam.
OriginalsprogEngelsk
TidsskriftThe Lancet Neurology
Vol/bind23
Udgave nummer2
Sider (fra-til)147-156
Antal sider10
ISSN1474-4422
DOI
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
Funding for the RESCUE ESES is provided by EpilepsieNL, WKZ fund, European Clinical Research Infrastructure Network, and Ming fund. This was an investigator-initiated study sponsored by the University Medical Center Utrecht, Utrecht, the Netherlands. We thank participating families who contributed to this study. We thank the (paediatric) neurologists for the referral of possible eligible participants: E A Cats (Gelre Hospitals, Apeldoorn, the Netherlands), N Geerdink (Rijnstate Hospital, Arnhem, Netherlands), V Roelfsema (Martini Hospital, Groningen, Netherlands), N Wolf, M Engelen, L A van de Pol, and D Bakker (Amsterdam University Medical Center, Amsterdam, Netherlands), M A A P Willemsen and J Schieving (Radboud University Medical Center, Nijmegen, Netherlands), E E O Hagebeuk, S Vrij, F Sprangers, W B Gunning, and K Geleijns (Stichting Epilepsie Instellingen Nederland, Heemstede, Netherlands), E Peeters (Juliana Children's Hospital, The Hague, Netherlands), and I Snoeck (University Medical Center Utrecht, Utrecht, Netherlands). Full members of the European Reference Network (ERN) EpiCARE are the University Medical Center Utrecht, Utrecht, Netherlands, University Hospitals of Lyon, Lyon, France, Helsinki University Hospital, Helsinki, Finland, and University of Freiburg, Freiburg, Germany. An affiliated member of ERN EpiCARE is the Danish Epilepsy Center, Dianalund, Denmark. A collaborating partner of ERN EpiCARE is Great Ormond Street Hospital for Children, London, UK.

Funding Information:
Funding for the RESCUE ESES is provided by EpilepsieNL, WKZ fund, European Clinical Research Infrastructure Network, and Ming fund. This was an investigator-initiated study sponsored by the University Medical Center Utrecht, Utrecht, the Netherlands. We thank participating families who contributed to this study. We thank the (paediatric) neurologists for the referral of possible eligible participants: E A Cats (Gelre Hospitals, Apeldoorn, the Netherlands), N Geerdink (Rijnstate Hospital, Arnhem, Netherlands), V Roelfsema (Martini Hospital, Groningen, Netherlands), N Wolf, M Engelen, L A van de Pol, and D Bakker (Amsterdam University Medical Center, Amsterdam, Netherlands), M A A P Willemsen and J Schieving (Radboud University Medical Center, Nijmegen, Netherlands), E E O Hagebeuk, S Vrij, F Sprangers, W B Gunning, and K Geleijns (Stichting Epilepsie Instellingen Nederland, Heemstede, Netherlands), E Peeters (Juliana Children's Hospital, The Hague, Netherlands), and I Snoeck (University Medical Center Utrecht, Utrecht, Netherlands). Full members of the European Reference Network (ERN) EpiCARE are the University Medical Center Utrecht, Utrecht, Netherlands, University Hospitals of Lyon, Lyon, France, Helsinki University Hospital, Helsinki, Finland, and University of Freiburg, Freiburg, Germany. An affiliated member of ERN EpiCARE is the Danish Epilepsy Center, Dianalund, Denmark. A collaborating partner of ERN EpiCARE is Great Ormond Street Hospital for Children, London, UK.

Publisher Copyright:
© 2023 Elsevier Ltd

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