Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
OBJECTIVE: To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS).
METHODS: Sixteen patients with newly diagnosed RRMS were studied by serial MRI and MR spectroscopic imaging (MRSI) once every 6 months for 24 months. Clinical examinations, including the expanded disability status scale (EDSS), were performed at baseline, month 24, and at year 7.
RESULTS: Baseline cortical NAA/Cr correlated inversely with EDSS at month 24 (r = -0·61, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline cortical NAA/Cr also correlated inversely with EDSS at the 7-year follow-up (r = -0·56, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline brain parenchymal fraction (BPF) correlated inversely with EDSS at month 24 (r = -0·61, P < 0·05), but not with EDSS at year 7.
DISCUSSION: Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome.
Originalsprog | Engelsk |
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Tidsskrift | Neurological Research |
Vol/bind | 36 |
Udgave nummer | 8 |
Sider (fra-til) | 701-708 |
Antal sider | 8 |
ISSN | 0161-6412 |
DOI | |
Status | Udgivet - aug. 2014 |
ID: 137436316