Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis
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Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis. / Wu, Xingchen; Hanson, Lars Grüner; Skimminge, Arnold; Sorensen, Per Soelberg; Paulson, Olaf Bjarne; Mathiesen, Henrik Kahr; Blinkenberg, Morten.
I: Neurological Research, Bind 36, Nr. 8, 08.2014, s. 701-708.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis
AU - Wu, Xingchen
AU - Hanson, Lars Grüner
AU - Skimminge, Arnold
AU - Sorensen, Per Soelberg
AU - Paulson, Olaf Bjarne
AU - Mathiesen, Henrik Kahr
AU - Blinkenberg, Morten
PY - 2014/8
Y1 - 2014/8
N2 - OBJECTIVE: To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS).METHODS: Sixteen patients with newly diagnosed RRMS were studied by serial MRI and MR spectroscopic imaging (MRSI) once every 6 months for 24 months. Clinical examinations, including the expanded disability status scale (EDSS), were performed at baseline, month 24, and at year 7.RESULTS: Baseline cortical NAA/Cr correlated inversely with EDSS at month 24 (r = -0·61, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline cortical NAA/Cr also correlated inversely with EDSS at the 7-year follow-up (r = -0·56, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline brain parenchymal fraction (BPF) correlated inversely with EDSS at month 24 (r = -0·61, P < 0·05), but not with EDSS at year 7.DISCUSSION: Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome.
AB - OBJECTIVE: To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS).METHODS: Sixteen patients with newly diagnosed RRMS were studied by serial MRI and MR spectroscopic imaging (MRSI) once every 6 months for 24 months. Clinical examinations, including the expanded disability status scale (EDSS), were performed at baseline, month 24, and at year 7.RESULTS: Baseline cortical NAA/Cr correlated inversely with EDSS at month 24 (r = -0·61, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline cortical NAA/Cr also correlated inversely with EDSS at the 7-year follow-up (r = -0·56, P < 0·05), and patients with EDSS ≧ 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P < 0·05). Baseline brain parenchymal fraction (BPF) correlated inversely with EDSS at month 24 (r = -0·61, P < 0·05), but not with EDSS at year 7.DISCUSSION: Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome.
KW - Adult
KW - Aspartic Acid
KW - Cerebral Cortex
KW - Creatine
KW - Disability Evaluation
KW - Disease Progression
KW - Female
KW - Humans
KW - Magnetic Resonance Spectroscopy
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis
KW - Prognosis
KW - Young Adult
U2 - 10.1179/1743132813Y.0000000312
DO - 10.1179/1743132813Y.0000000312
M3 - Journal article
C2 - 24620975
VL - 36
SP - 701
EP - 708
JO - Neurological Research
JF - Neurological Research
SN - 0161-6412
IS - 8
ER -
ID: 137436316