Copeptin in anorexia nervosa
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Copeptin in anorexia nervosa. / Goetze, Jens P.; Støving, René Klinkby.
I: Brain and Behavior, Bind 10, Nr. 4, e01551, 2020, s. 1-4.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Copeptin in anorexia nervosa
AU - Goetze, Jens P.
AU - Støving, René Klinkby
N1 - Publisher Copyright: © 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
PY - 2020
Y1 - 2020
N2 - Objective: Antidiuretic hormone (ADH) is involved in the response to stress and in depression and anxiety. However, studies on ADH in anorexia nervosa (AN) show conflicting results. A major reason for this may be methodological challenges due to short half-life of ADH in circulation and rapid degradation in vitro. To overcome these obstacles, copeptin, the C-terminal fragment stemming from the ADH precursor, has been increasingly used as a stable clinical measure for ADH. Furthermore, copeptin has been recognized as a biomarker of insulin resistance in obesity. Methods: We measured fasting copeptin in plasma from 25 normohydrated, stable women with AN (BMI 13.0 ± 2.0) and 25 age-matched women. Results: No difference in copeptin levels was found (6.8 ± 1.8 vs. 5.5 ± 0.5 pmol/L). Confirmatory, copeptin concentrations were correlated to insulin resistance assessed by the homeostasis model assessment of insulin resistance. Discussion: We report for the first time that copeptin level as a marker of ADH activity is not altered in fluid- and electrolyte-stabilized patients with severe AN patients, indicating that ADH may not be crucial in the pathophysiological involvement of psychologic stress in AN.
AB - Objective: Antidiuretic hormone (ADH) is involved in the response to stress and in depression and anxiety. However, studies on ADH in anorexia nervosa (AN) show conflicting results. A major reason for this may be methodological challenges due to short half-life of ADH in circulation and rapid degradation in vitro. To overcome these obstacles, copeptin, the C-terminal fragment stemming from the ADH precursor, has been increasingly used as a stable clinical measure for ADH. Furthermore, copeptin has been recognized as a biomarker of insulin resistance in obesity. Methods: We measured fasting copeptin in plasma from 25 normohydrated, stable women with AN (BMI 13.0 ± 2.0) and 25 age-matched women. Results: No difference in copeptin levels was found (6.8 ± 1.8 vs. 5.5 ± 0.5 pmol/L). Confirmatory, copeptin concentrations were correlated to insulin resistance assessed by the homeostasis model assessment of insulin resistance. Discussion: We report for the first time that copeptin level as a marker of ADH activity is not altered in fluid- and electrolyte-stabilized patients with severe AN patients, indicating that ADH may not be crucial in the pathophysiological involvement of psychologic stress in AN.
KW - anorexia nervosa
KW - antidiuretic hormone
KW - arginine vasopressin
KW - copeptin
KW - insulin
UR - http://www.scopus.com/inward/record.url?scp=85079880018&partnerID=8YFLogxK
U2 - 10.1002/brb3.1551
DO - 10.1002/brb3.1551
M3 - Journal article
C2 - 32073757
AN - SCOPUS:85079880018
VL - 10
SP - 1
EP - 4
JO - Brain and Behavior
JF - Brain and Behavior
SN - 2157-9032
IS - 4
M1 - e01551
ER -
ID: 270209942