Complete clearance of severe plaque psoriasis with 24 weeks of oral roflumilast therapy
Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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Complete clearance of severe plaque psoriasis with 24 weeks of oral roflumilast therapy. / Egeberg, A.; Meteran, H.; Gyldenløve, M.; Zachariae, C.
I: British Journal of Dermatology, Bind 185, Nr. 6, 2021, s. 1251-1252.Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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TY - JOUR
T1 - Complete clearance of severe plaque psoriasis with 24 weeks of oral roflumilast therapy
AU - Egeberg, A.
AU - Meteran, H.
AU - Gyldenløve, M.
AU - Zachariae, C.
PY - 2021
Y1 - 2021
N2 - Current psoriasis therapies have little-to-no effect on comorbidities such as obesity and chronic obstructive pulmonary disease (COPD). Apremilast, a phosphodiesterase 4 (PDE-4) inhibitor, is approved for moderate-to-severe psoriasis and considered a safe treatment option, that does not require laboratory monitoring. Nonetheless, lower efficacy compared with novel similar priced biologics, have led to modest use of apremilast in some countries. Roflumilast, a selective oral PDE-4 inhibitor, is approved for severe COPD in the US and EU. A common side effect of roflumilast therapy is weight loss, which has limited its use in COPD, where underweight is frequently observed.
AB - Current psoriasis therapies have little-to-no effect on comorbidities such as obesity and chronic obstructive pulmonary disease (COPD). Apremilast, a phosphodiesterase 4 (PDE-4) inhibitor, is approved for moderate-to-severe psoriasis and considered a safe treatment option, that does not require laboratory monitoring. Nonetheless, lower efficacy compared with novel similar priced biologics, have led to modest use of apremilast in some countries. Roflumilast, a selective oral PDE-4 inhibitor, is approved for severe COPD in the US and EU. A common side effect of roflumilast therapy is weight loss, which has limited its use in COPD, where underweight is frequently observed.
U2 - 10.1111/bjd.20602
DO - 10.1111/bjd.20602
M3 - Letter
C2 - 34184248
VL - 185
SP - 1251
EP - 1252
JO - British Journal of Dermatology, Supplement
JF - British Journal of Dermatology, Supplement
SN - 0366-077X
IS - 6
ER -
ID: 276230941