Cohort study evaluating predictors of therapeutic success after sleeve gastrectomy or Roux-en-Y gastric bypass
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Cohort study evaluating predictors of therapeutic success after sleeve gastrectomy or Roux-en-Y gastric bypass. / Grandt, Josephine; Chang, Johannes; Turler, Andreas; Jansen, Christian; Schierwagen, Robert; Schröder, Tatjana; Praktiknjo, Michael; Strassburg, Christian P; Spengler, Ulrich; Trebicka, Jonel; Gluud, Lise Lotte.
I: Annals of Laparoscopic and Endoscopic Surgery, Bind 7, 1, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cohort study evaluating predictors of therapeutic success after sleeve gastrectomy or Roux-en-Y gastric bypass
AU - Grandt, Josephine
AU - Chang, Johannes
AU - Turler, Andreas
AU - Jansen, Christian
AU - Schierwagen, Robert
AU - Schröder, Tatjana
AU - Praktiknjo, Michael
AU - Strassburg, Christian P
AU - Spengler, Ulrich
AU - Trebicka, Jonel
AU - Gluud, Lise Lotte
N1 - Publisher Copyright: © 2022 Territorios. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Background: Bariatric surgery is an effective treatment for several patients, but some may not achieve sufficient weight loss. We therefore evaluated predictors of adequate weight loss defined as ≥50% excess weight loss (EWL). Methods: Retrospective cohort study including patients who underwent sleeve gastrectomy (SG) or Roux-Y-gastric bypass (RYGB) followed for 12 months. Results: A total of 170 patients [81.2% female, age 42 years, 19.4% type 2 diabetes (T2D), body mass index (BMI) 49.4 kg/m2] were included. Type of surgery was SG (71.2%) or RYGB (28.8%). After surgery, the median BMI decreased to 34.9 (30.0-40.5) kg/m2. The median %EWL was 57.7 (41.6-69.7). Pre-operative weight loss was not associated with %EWL (P=0.25). Patients who achieved therapeutic success had a lower baseline median BMI of 48.0 (IQR, 42.9-51.6) kg/m2 whereas those who did not had a median BMI of 52.0 (IQR, 48.0-58.5) kg/m2 and the baseline BMI was correlated with the %EWL (P<0.001). Gender, age, and surgical method did not predict therapeutic success. The baseline BMI and T2D were the only predictors in logistic regression analysis. Conclusions: A lower baseline BMI and absence of T2D predicted therapeutic success and %EWL. RYGB and SG performed equally well, but the proportion of patients with T2D was higher in RYBG what may have influenced the outcome. Additional research is needed to evaluate the findings.
AB - Background: Bariatric surgery is an effective treatment for several patients, but some may not achieve sufficient weight loss. We therefore evaluated predictors of adequate weight loss defined as ≥50% excess weight loss (EWL). Methods: Retrospective cohort study including patients who underwent sleeve gastrectomy (SG) or Roux-Y-gastric bypass (RYGB) followed for 12 months. Results: A total of 170 patients [81.2% female, age 42 years, 19.4% type 2 diabetes (T2D), body mass index (BMI) 49.4 kg/m2] were included. Type of surgery was SG (71.2%) or RYGB (28.8%). After surgery, the median BMI decreased to 34.9 (30.0-40.5) kg/m2. The median %EWL was 57.7 (41.6-69.7). Pre-operative weight loss was not associated with %EWL (P=0.25). Patients who achieved therapeutic success had a lower baseline median BMI of 48.0 (IQR, 42.9-51.6) kg/m2 whereas those who did not had a median BMI of 52.0 (IQR, 48.0-58.5) kg/m2 and the baseline BMI was correlated with the %EWL (P<0.001). Gender, age, and surgical method did not predict therapeutic success. The baseline BMI and T2D were the only predictors in logistic regression analysis. Conclusions: A lower baseline BMI and absence of T2D predicted therapeutic success and %EWL. RYGB and SG performed equally well, but the proportion of patients with T2D was higher in RYBG what may have influenced the outcome. Additional research is needed to evaluate the findings.
KW - Bariatric surgery
KW - liver enzymes
KW - obesity
KW - weight loss
U2 - 10.21037/ales-21-2
DO - 10.21037/ales-21-2
M3 - Journal article
AN - SCOPUS:85129890282
VL - 7
JO - Annals of Laparoscopic and Endoscopic Surgery
JF - Annals of Laparoscopic and Endoscopic Surgery
SN - 2518-6973
M1 - 1
ER -
ID: 317239938