Coagulation parameters in the newborn and infant: The Copenhagen Baby Heart and COMPARE studies

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Coagulation parameters in the newborn and infant : The Copenhagen Baby Heart and COMPARE studies. / Nielsen, Sofie Taageby; Strandkjær, Nina; Juul Rasmussen, Ida; Hansen, Malene Kongsgaard; Lytsen, Rikke Mohr; Kamstrup, Pia R.; Rode, Line; Goetze, Jens P.; Iversen, Kasper; Bundgaard, Henning; Frikke-Schmidt, Ruth.

I: Clinical Chemistry and Laboratory Medicine, Bind 60, Nr. 2, 2022, s. 261-270.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Nielsen, ST, Strandkjær, N, Juul Rasmussen, I, Hansen, MK, Lytsen, RM, Kamstrup, PR, Rode, L, Goetze, JP, Iversen, K, Bundgaard, H & Frikke-Schmidt, R 2022, 'Coagulation parameters in the newborn and infant: The Copenhagen Baby Heart and COMPARE studies', Clinical Chemistry and Laboratory Medicine, bind 60, nr. 2, s. 261-270. https://doi.org/10.1515/cclm-2021-0967

APA

Nielsen, S. T., Strandkjær, N., Juul Rasmussen, I., Hansen, M. K., Lytsen, R. M., Kamstrup, P. R., Rode, L., Goetze, J. P., Iversen, K., Bundgaard, H., & Frikke-Schmidt, R. (2022). Coagulation parameters in the newborn and infant: The Copenhagen Baby Heart and COMPARE studies. Clinical Chemistry and Laboratory Medicine, 60(2), 261-270. https://doi.org/10.1515/cclm-2021-0967

Vancouver

Nielsen ST, Strandkjær N, Juul Rasmussen I, Hansen MK, Lytsen RM, Kamstrup PR o.a. Coagulation parameters in the newborn and infant: The Copenhagen Baby Heart and COMPARE studies. Clinical Chemistry and Laboratory Medicine. 2022;60(2):261-270. https://doi.org/10.1515/cclm-2021-0967

Author

Nielsen, Sofie Taageby ; Strandkjær, Nina ; Juul Rasmussen, Ida ; Hansen, Malene Kongsgaard ; Lytsen, Rikke Mohr ; Kamstrup, Pia R. ; Rode, Line ; Goetze, Jens P. ; Iversen, Kasper ; Bundgaard, Henning ; Frikke-Schmidt, Ruth. / Coagulation parameters in the newborn and infant : The Copenhagen Baby Heart and COMPARE studies. I: Clinical Chemistry and Laboratory Medicine. 2022 ; Bind 60, Nr. 2. s. 261-270.

Bibtex

@article{7c1c21053d404a019b2cf75a60b77855,
title = "Coagulation parameters in the newborn and infant: The Copenhagen Baby Heart and COMPARE studies",
abstract = "The coagulation system is not fully developed at birth and matures during the first months of infancy, complicating clinical decision making within hemostasis. This study evaluates coagulation parameters at birth and two months after birth, and tests whether cord blood can be used as a proxy for neonatal venous blood measurements. The Copenhagen Baby Heart Study (CBHS) and the COMPARE study comprise 13,237 cord blood samples and 444 parallel neonatal venous blood samples, with a two month follow-up in 362 children. Because coagulation parameters differed according to gestational age (GA), all analyses were stratified by GA. For neonatal venous blood, reference intervals for activated partial thromboplastin time (APTT) and prothrombin time (PT) were 28-43 s and 33-61% for GA 37-39 and 24-38 s and 30-65% for GA 40-42. Reference intervals for international normalized ratio (INR) and thrombocyte count were 1.1-1.7 and 194-409 × 109/L for GA 37-39 and 1.2-1.8 and 188-433 × 109/L for GA 40-42. Correlation coefficients between umbilical cord and neonatal venous blood for APTT, PT, INR, and thrombocyte count were 0.68, 0.72, 0.69, and 0.77 respectively, and the distributions of the parameters did not differ between the two types of blood (all p-values>0.05). This study describes new GA dependent reference intervals for common coagulation parameters in newborns and suggests that cord blood may serve as a proxy for neonatal venous blood for these traits. Such data will likely improve clinical decision making within hemostasis among newborn and infant children. ",
keywords = "coagulation, cord blood, hemostasis, neonatology, reference intervals",
author = "Nielsen, {Sofie Taageby} and Nina Strandkj{\ae}r and {Juul Rasmussen}, Ida and Hansen, {Malene Kongsgaard} and Lytsen, {Rikke Mohr} and Kamstrup, {Pia R.} and Line Rode and Goetze, {Jens P.} and Kasper Iversen and Henning Bundgaard and Ruth Frikke-Schmidt",
year = "2022",
doi = "10.1515/cclm-2021-0967",
language = "English",
volume = "60",
pages = "261--270",
journal = "Clinical Chemistry and Laboratory Medicine",
issn = "1434-6621",
publisher = "Walterde Gruyter GmbH",
number = "2",

}

RIS

TY - JOUR

T1 - Coagulation parameters in the newborn and infant

T2 - The Copenhagen Baby Heart and COMPARE studies

AU - Nielsen, Sofie Taageby

AU - Strandkjær, Nina

AU - Juul Rasmussen, Ida

AU - Hansen, Malene Kongsgaard

AU - Lytsen, Rikke Mohr

AU - Kamstrup, Pia R.

AU - Rode, Line

AU - Goetze, Jens P.

AU - Iversen, Kasper

AU - Bundgaard, Henning

AU - Frikke-Schmidt, Ruth

PY - 2022

Y1 - 2022

N2 - The coagulation system is not fully developed at birth and matures during the first months of infancy, complicating clinical decision making within hemostasis. This study evaluates coagulation parameters at birth and two months after birth, and tests whether cord blood can be used as a proxy for neonatal venous blood measurements. The Copenhagen Baby Heart Study (CBHS) and the COMPARE study comprise 13,237 cord blood samples and 444 parallel neonatal venous blood samples, with a two month follow-up in 362 children. Because coagulation parameters differed according to gestational age (GA), all analyses were stratified by GA. For neonatal venous blood, reference intervals for activated partial thromboplastin time (APTT) and prothrombin time (PT) were 28-43 s and 33-61% for GA 37-39 and 24-38 s and 30-65% for GA 40-42. Reference intervals for international normalized ratio (INR) and thrombocyte count were 1.1-1.7 and 194-409 × 109/L for GA 37-39 and 1.2-1.8 and 188-433 × 109/L for GA 40-42. Correlation coefficients between umbilical cord and neonatal venous blood for APTT, PT, INR, and thrombocyte count were 0.68, 0.72, 0.69, and 0.77 respectively, and the distributions of the parameters did not differ between the two types of blood (all p-values>0.05). This study describes new GA dependent reference intervals for common coagulation parameters in newborns and suggests that cord blood may serve as a proxy for neonatal venous blood for these traits. Such data will likely improve clinical decision making within hemostasis among newborn and infant children.

AB - The coagulation system is not fully developed at birth and matures during the first months of infancy, complicating clinical decision making within hemostasis. This study evaluates coagulation parameters at birth and two months after birth, and tests whether cord blood can be used as a proxy for neonatal venous blood measurements. The Copenhagen Baby Heart Study (CBHS) and the COMPARE study comprise 13,237 cord blood samples and 444 parallel neonatal venous blood samples, with a two month follow-up in 362 children. Because coagulation parameters differed according to gestational age (GA), all analyses were stratified by GA. For neonatal venous blood, reference intervals for activated partial thromboplastin time (APTT) and prothrombin time (PT) were 28-43 s and 33-61% for GA 37-39 and 24-38 s and 30-65% for GA 40-42. Reference intervals for international normalized ratio (INR) and thrombocyte count were 1.1-1.7 and 194-409 × 109/L for GA 37-39 and 1.2-1.8 and 188-433 × 109/L for GA 40-42. Correlation coefficients between umbilical cord and neonatal venous blood for APTT, PT, INR, and thrombocyte count were 0.68, 0.72, 0.69, and 0.77 respectively, and the distributions of the parameters did not differ between the two types of blood (all p-values>0.05). This study describes new GA dependent reference intervals for common coagulation parameters in newborns and suggests that cord blood may serve as a proxy for neonatal venous blood for these traits. Such data will likely improve clinical decision making within hemostasis among newborn and infant children.

KW - coagulation

KW - cord blood

KW - hemostasis

KW - neonatology

KW - reference intervals

U2 - 10.1515/cclm-2021-0967

DO - 10.1515/cclm-2021-0967

M3 - Journal article

C2 - 34752018

AN - SCOPUS:85119398122

VL - 60

SP - 261

EP - 270

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

SN - 1434-6621

IS - 2

ER -

ID: 286013894