Clinical implications of electrocardiographic bundle branch block in primary care
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Clinical implications of electrocardiographic bundle branch block in primary care. / Rasmussen, Peter Vibe; Skov, Morten Wagner; Ghouse, Jonas; Pietersen, Adrian; Hansen, Steen Moller; Torp-Pedersen, Christian; Kober, Lars; Haunso, Stig; Olesen, Morten Salling; Svendsen, Jesper Hastrup; Melgaard, Jacob; Graff, Claus; Holst, Anders Gaardsdal; Nielsen, Jonas Bille.
I: Heart, Bind 105, Nr. 15, 2019, s. 1160-1167.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Clinical implications of electrocardiographic bundle branch block in primary care
AU - Rasmussen, Peter Vibe
AU - Skov, Morten Wagner
AU - Ghouse, Jonas
AU - Pietersen, Adrian
AU - Hansen, Steen Moller
AU - Torp-Pedersen, Christian
AU - Kober, Lars
AU - Haunso, Stig
AU - Olesen, Morten Salling
AU - Svendsen, Jesper Hastrup
AU - Melgaard, Jacob
AU - Graff, Claus
AU - Holst, Anders Gaardsdal
AU - Nielsen, Jonas Bille
PY - 2019
Y1 - 2019
N2 - Objectives Electrocardiographic bundle branch block (BBB) is common but the prognostic implications in primary care are unclear. We sought to investigate the relationship between electrocardiographic BBB subtypes and the risk of cardiovascular (CV) outcomes in a primary care population free of major CV disease. Methods Retrospective cohort study of primary care patients referred for electrocardiogram (ECG) recording between 2001 and 2011. Cox regression models were used to estimate hazard ratios (HR) as well as absolute risks of CV outcomes based on various BBB subtypes. Results We included 202 268 individuals with a median follow-up period of 7.8 years (Inter-quartile range [IQR] 4.9-10.6). Left bundle branch block (LBBB) was associated with heart failure (HF) in both men (HR 3.96, 95% CI 3.30 to 4.76) and women (HR 2.51, 95% CI 2.15 to 2.94) and with CV death in men (HR 1.80, 95% CI 1.38 to 2.35). Right bundle branch block (RBBB) was associated with pacemaker implantation in both men (HR 3.26, 95% CI 2.74 to 3.89) and women (HR 3.69, 95% CI 2.91 to 4.67), HF in both sexes and weakly associated with CV death in men. Regarding LBBB, we found an increasing hazard of HF with increasing QRS-interval duration (HR 1.25, 95% CI 1.11 to 1.42 per 10 ms increase in men and HR 1.23, 95% CI 1.08 to 1.40 per 10 ms increase in women). Absolute 10-year risk predictions across age-specific and sex-specific subgroups revealed clinically relevant differences between having various BBB subtypes. Conclusions Opportunistic findings of BBB subtypes in primary care patients without major CV disease should be considered warnings of future HF and pacemaker implantation
AB - Objectives Electrocardiographic bundle branch block (BBB) is common but the prognostic implications in primary care are unclear. We sought to investigate the relationship between electrocardiographic BBB subtypes and the risk of cardiovascular (CV) outcomes in a primary care population free of major CV disease. Methods Retrospective cohort study of primary care patients referred for electrocardiogram (ECG) recording between 2001 and 2011. Cox regression models were used to estimate hazard ratios (HR) as well as absolute risks of CV outcomes based on various BBB subtypes. Results We included 202 268 individuals with a median follow-up period of 7.8 years (Inter-quartile range [IQR] 4.9-10.6). Left bundle branch block (LBBB) was associated with heart failure (HF) in both men (HR 3.96, 95% CI 3.30 to 4.76) and women (HR 2.51, 95% CI 2.15 to 2.94) and with CV death in men (HR 1.80, 95% CI 1.38 to 2.35). Right bundle branch block (RBBB) was associated with pacemaker implantation in both men (HR 3.26, 95% CI 2.74 to 3.89) and women (HR 3.69, 95% CI 2.91 to 4.67), HF in both sexes and weakly associated with CV death in men. Regarding LBBB, we found an increasing hazard of HF with increasing QRS-interval duration (HR 1.25, 95% CI 1.11 to 1.42 per 10 ms increase in men and HR 1.23, 95% CI 1.08 to 1.40 per 10 ms increase in women). Absolute 10-year risk predictions across age-specific and sex-specific subgroups revealed clinically relevant differences between having various BBB subtypes. Conclusions Opportunistic findings of BBB subtypes in primary care patients without major CV disease should be considered warnings of future HF and pacemaker implantation
KW - electrocardiography
KW - heart failure
KW - pacemakers
KW - cardiac risk factors and prevention
U2 - 10.1136/heartjnl-2018-314295
DO - 10.1136/heartjnl-2018-314295
M3 - Journal article
C2 - 31129608
VL - 105
SP - 1160
EP - 1167
JO - Heart
JF - Heart
SN - 1355-6037
IS - 15
ER -
ID: 225476959