Cimetidin og kreatininclearance

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Standard

Cimetidin og kreatininclearance. / Olsen, Niels Vidiendal; Ladefoged, S D; Feldt-Rasmussen, B F; Fogh-Andersen, N; Munck, O.

I: Ugeskrift for Laeger, Bind 151, Nr. 35, 28.08.1989, s. 2202-3.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Olsen, NV, Ladefoged, SD, Feldt-Rasmussen, BF, Fogh-Andersen, N & Munck, O 1989, 'Cimetidin og kreatininclearance', Ugeskrift for Laeger, bind 151, nr. 35, s. 2202-3.

APA

Olsen, N. V., Ladefoged, S. D., Feldt-Rasmussen, B. F., Fogh-Andersen, N., & Munck, O. (1989). Cimetidin og kreatininclearance. Ugeskrift for Laeger, 151(35), 2202-3.

Vancouver

Olsen NV, Ladefoged SD, Feldt-Rasmussen BF, Fogh-Andersen N, Munck O. Cimetidin og kreatininclearance. Ugeskrift for Laeger. 1989 aug. 28;151(35):2202-3.

Author

Olsen, Niels Vidiendal ; Ladefoged, S D ; Feldt-Rasmussen, B F ; Fogh-Andersen, N ; Munck, O. / Cimetidin og kreatininclearance. I: Ugeskrift for Laeger. 1989 ; Bind 151, Nr. 35. s. 2202-3.

Bibtex

@article{aaa1d590e91c4d9f8b6e7fd4bdde607b,
title = "Cimetidin og kreatininclearance",
abstract = "Cimetidine lowers secretion of creatinine in the renal tubuli in healthy individuals and persons with chronic renal disease. The conditions in patients with renal transplants have hitherto been unknown. The renal clearance of endogenic creatinine (CKrea) was investigated prior to and after an intravenous bolus injektion of cimetidine (5 mg/kg) in nine patients with renal transplants. The rate of glomerular filtration (GFR) was determined by clearance investigation of 125I-thalamate (CTh). CKrea fell 29% from 65 ml/min (median) to 46 ml/min (p less than 0.01), whereas GFR remained unchanged. The fractionated creatinine clearance (CKrea/CTh) fell therefore from 1.43 (median) to 1.03 (p less than 0.01). It is concluded that cimetidine reduces creatinine secretion in patients with renal transplants and this should be borne in mind when the function of the graft is assessed solely with CKrea.",
keywords = "Adult, Cimetidine, Creatinine, Glomerular Filtration Rate, Humans, Injections, Intravenous, Kidney Transplantation, Middle Aged",
author = "Olsen, {Niels Vidiendal} and Ladefoged, {S D} and Feldt-Rasmussen, {B F} and N Fogh-Andersen and O Munck",
year = "1989",
month = aug,
day = "28",
language = "Dansk",
volume = "151",
pages = "2202--3",
journal = "Ugeskrift for Laeger",
issn = "0041-5782",
publisher = "Almindelige Danske Laegeforening",
number = "35",

}

RIS

TY - JOUR

T1 - Cimetidin og kreatininclearance

AU - Olsen, Niels Vidiendal

AU - Ladefoged, S D

AU - Feldt-Rasmussen, B F

AU - Fogh-Andersen, N

AU - Munck, O

PY - 1989/8/28

Y1 - 1989/8/28

N2 - Cimetidine lowers secretion of creatinine in the renal tubuli in healthy individuals and persons with chronic renal disease. The conditions in patients with renal transplants have hitherto been unknown. The renal clearance of endogenic creatinine (CKrea) was investigated prior to and after an intravenous bolus injektion of cimetidine (5 mg/kg) in nine patients with renal transplants. The rate of glomerular filtration (GFR) was determined by clearance investigation of 125I-thalamate (CTh). CKrea fell 29% from 65 ml/min (median) to 46 ml/min (p less than 0.01), whereas GFR remained unchanged. The fractionated creatinine clearance (CKrea/CTh) fell therefore from 1.43 (median) to 1.03 (p less than 0.01). It is concluded that cimetidine reduces creatinine secretion in patients with renal transplants and this should be borne in mind when the function of the graft is assessed solely with CKrea.

AB - Cimetidine lowers secretion of creatinine in the renal tubuli in healthy individuals and persons with chronic renal disease. The conditions in patients with renal transplants have hitherto been unknown. The renal clearance of endogenic creatinine (CKrea) was investigated prior to and after an intravenous bolus injektion of cimetidine (5 mg/kg) in nine patients with renal transplants. The rate of glomerular filtration (GFR) was determined by clearance investigation of 125I-thalamate (CTh). CKrea fell 29% from 65 ml/min (median) to 46 ml/min (p less than 0.01), whereas GFR remained unchanged. The fractionated creatinine clearance (CKrea/CTh) fell therefore from 1.43 (median) to 1.03 (p less than 0.01). It is concluded that cimetidine reduces creatinine secretion in patients with renal transplants and this should be borne in mind when the function of the graft is assessed solely with CKrea.

KW - Adult

KW - Cimetidine

KW - Creatinine

KW - Glomerular Filtration Rate

KW - Humans

KW - Injections, Intravenous

KW - Kidney Transplantation

KW - Middle Aged

M3 - Tidsskriftartikel

C2 - 2675442

VL - 151

SP - 2202

EP - 2203

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

SN - 0041-5782

IS - 35

ER -

ID: 47241077