Chemical biology strategies for biofilm control
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
Signaling pathways are required for bacterial biofilm formation and antimicrobial resistance. Among them, quorum sensing (QS) and c-di-GMP signaling are the best characterized. QS is a widely distributed intercellular signaling mechanism by which microorganisms regulate gene expression in response to small diffusible signaling molecules (1). Bacteria have developed oligopeptides, N-acyl homoserine lactones (HSLs), and autoinducer-2 as signal molecules (1). When the QS signal molecules reach a local threshold concentration, they can interact with specific receptors and impact the expression of hundreds of genes. Many of the QS-regulated genes (motility, biosurfacant synthesis, EPS synthesis) are required for the biofilm formation and antibiotic resistance of various bacterial species (2).
Originalsprog | Engelsk |
---|---|
Titel | Microbial Biofilms |
Antal sider | 10 |
Forlag | Wiley-Interscience |
Publikationsdato | 1 jan. 2015 |
Sider | 363-372 |
Kapitel | 18 |
ISBN (Trykt) | 9781555817459 |
ISBN (Elektronisk) | 9781683670919 |
DOI | |
Status | Udgivet - 1 jan. 2015 |
Bibliografisk note
Publisher Copyright:
© 2015 by ASM Press.
ID: 340025918