TY - JOUR

T1 - Characteristics and drivers of fatigue in patients with psoriasis and psoriatic arthritis

T2 - A cross sectional study

AU - Nymand, Lea

AU - Kristensen, Lars Erik

AU - Thomsen, Simon Francis

AU - Thyssen, Jacob P.

AU - Egeberg, Alexander

N1 - Publisher Copyright: © 2024 American Academy of Dermatology, Inc.

PY - 2024

Y1 - 2024

N2 - Background: A multitude of factors may influence fatigue in psoriasis and psoriatic arthritis (PsA); however, their individual fatigue components have not been thoroughly examined. Objectives: To explore characteristics of fatigue and its potential drivers in a cohort of patients with psoriasis with or without PsA. Methods: Adults with psoriasis and a nonpsoriasis control group completed the Multidimensional Fatigue Inventory-20 questionnaire. Patients with psoriasis also reported joint pain intensity, pruritus, skin pain, and sleep problems using a numerical rating scale. Linear regression models were applied to continuous outcomes, and beta coefficients (β) for the slopes were estimated with 95% confidence intervals (CIs). Results: Among 2741 adults with psoriasis (of which 593 also had PsA) and 3788 controls, the impact on total fatigue was greatest for PsA (β = 5.22; 95% CI, 3.55-6.90), followed by psoriasis (β = 2.10; 95% CI, 0.96-3.25), compared with the general population (Ptrend <.0001). Among patients with psoriasis with or without PsA, increasing joint pain intensity was associated with overall fatigue (β = 2.23 [95% CI, 2.03-2.44] for each 1-point increase in joint pain numerical rating scale score). Limitations: We lacked information on the effect of pharmacotherapy. Conclusions: These findings highlight the importance of a symptom-based approach when treating psoriasis, rather than focusing on objective severity measures alone.

AB - Background: A multitude of factors may influence fatigue in psoriasis and psoriatic arthritis (PsA); however, their individual fatigue components have not been thoroughly examined. Objectives: To explore characteristics of fatigue and its potential drivers in a cohort of patients with psoriasis with or without PsA. Methods: Adults with psoriasis and a nonpsoriasis control group completed the Multidimensional Fatigue Inventory-20 questionnaire. Patients with psoriasis also reported joint pain intensity, pruritus, skin pain, and sleep problems using a numerical rating scale. Linear regression models were applied to continuous outcomes, and beta coefficients (β) for the slopes were estimated with 95% confidence intervals (CIs). Results: Among 2741 adults with psoriasis (of which 593 also had PsA) and 3788 controls, the impact on total fatigue was greatest for PsA (β = 5.22; 95% CI, 3.55-6.90), followed by psoriasis (β = 2.10; 95% CI, 0.96-3.25), compared with the general population (Ptrend <.0001). Among patients with psoriasis with or without PsA, increasing joint pain intensity was associated with overall fatigue (β = 2.23 [95% CI, 2.03-2.44] for each 1-point increase in joint pain numerical rating scale score). Limitations: We lacked information on the effect of pharmacotherapy. Conclusions: These findings highlight the importance of a symptom-based approach when treating psoriasis, rather than focusing on objective severity measures alone.

KW - burden

KW - comorbidity

KW - fatigue

KW - psoriasis

KW - psoriatic arthritis

KW - quality of life

UR - http://www.scopus.com/inward/record.url?scp=85188509149&partnerID=8YFLogxK

U2 - 10.1016/j.jaad.2024.02.026

DO - 10.1016/j.jaad.2024.02.026

M3 - Journal article

C2 - 38395230

AN - SCOPUS:85188509149

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

SN - 0190-9622

ER -