Changes of laminin beta 2 chain expression in congenital muscular dystrophy

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Changes of laminin beta 2 chain expression in congenital muscular dystrophy. / Cohn, R D; Herrmann, R; Wewer, U M; Voit, T.

I: Neuromuscular Disorders, Bind 7, Nr. 6-7, 01.09.1997, s. 373-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Cohn, RD, Herrmann, R, Wewer, UM & Voit, T 1997, 'Changes of laminin beta 2 chain expression in congenital muscular dystrophy', Neuromuscular Disorders, bind 7, nr. 6-7, s. 373-8.

APA

Cohn, R. D., Herrmann, R., Wewer, U. M., & Voit, T. (1997). Changes of laminin beta 2 chain expression in congenital muscular dystrophy. Neuromuscular Disorders, 7(6-7), 373-8.

Vancouver

Cohn RD, Herrmann R, Wewer UM, Voit T. Changes of laminin beta 2 chain expression in congenital muscular dystrophy. Neuromuscular Disorders. 1997 sep. 1;7(6-7):373-8.

Author

Cohn, R D ; Herrmann, R ; Wewer, U M ; Voit, T. / Changes of laminin beta 2 chain expression in congenital muscular dystrophy. I: Neuromuscular Disorders. 1997 ; Bind 7, Nr. 6-7. s. 373-8.

Bibtex

@article{70de898106bc4e9cb358c164269bb2ae,
title = "Changes of laminin beta 2 chain expression in congenital muscular dystrophy",
abstract = "We studied the distribution of laminin beta 2 chain in the skeletal muscle basement membrane of 16 patients with congenital muscular dystrophy (CMD) by immunohistochemistry. A dramatic reduction in the laminin beta 2 staining was observed in four patients with classical merosin-negative CMD. A moderate reduction of laminin beta 2 labelling was observed in four patients with partial merosin deficiency and two patients with merosin-positive CMD. Two patients with merosin-positive CMD had no apparent changes in the expression of laminin beta 2. In three patients and one fetus diagnosed as Walker-Warburg syndrome (WWS) the laminin beta 2 pattern was similar to normal controls. We conclude that a primary deficiency in the laminin alpha 2 chain may lead to a vast or moderate reduction in the laminin beta 2 chain in the skeletal muscle membrane.",
keywords = "Adolescent, Child, Child, Preschool, Female, Fluorescent Antibody Technique, Direct, Humans, Immunohistochemistry, Infant, Laminin, Male, Muscular Dystrophies, Pregnancy",
author = "Cohn, {R D} and R Herrmann and Wewer, {U M} and T Voit",
year = "1997",
month = sep,
day = "1",
language = "English",
volume = "7",
pages = "373--8",
journal = "Journal of Neuromuscular Diseases",
issn = "0960-8966",
publisher = "Elsevier",
number = "6-7",

}

RIS

TY - JOUR

T1 - Changes of laminin beta 2 chain expression in congenital muscular dystrophy

AU - Cohn, R D

AU - Herrmann, R

AU - Wewer, U M

AU - Voit, T

PY - 1997/9/1

Y1 - 1997/9/1

N2 - We studied the distribution of laminin beta 2 chain in the skeletal muscle basement membrane of 16 patients with congenital muscular dystrophy (CMD) by immunohistochemistry. A dramatic reduction in the laminin beta 2 staining was observed in four patients with classical merosin-negative CMD. A moderate reduction of laminin beta 2 labelling was observed in four patients with partial merosin deficiency and two patients with merosin-positive CMD. Two patients with merosin-positive CMD had no apparent changes in the expression of laminin beta 2. In three patients and one fetus diagnosed as Walker-Warburg syndrome (WWS) the laminin beta 2 pattern was similar to normal controls. We conclude that a primary deficiency in the laminin alpha 2 chain may lead to a vast or moderate reduction in the laminin beta 2 chain in the skeletal muscle membrane.

AB - We studied the distribution of laminin beta 2 chain in the skeletal muscle basement membrane of 16 patients with congenital muscular dystrophy (CMD) by immunohistochemistry. A dramatic reduction in the laminin beta 2 staining was observed in four patients with classical merosin-negative CMD. A moderate reduction of laminin beta 2 labelling was observed in four patients with partial merosin deficiency and two patients with merosin-positive CMD. Two patients with merosin-positive CMD had no apparent changes in the expression of laminin beta 2. In three patients and one fetus diagnosed as Walker-Warburg syndrome (WWS) the laminin beta 2 pattern was similar to normal controls. We conclude that a primary deficiency in the laminin alpha 2 chain may lead to a vast or moderate reduction in the laminin beta 2 chain in the skeletal muscle membrane.

KW - Adolescent

KW - Child

KW - Child, Preschool

KW - Female

KW - Fluorescent Antibody Technique, Direct

KW - Humans

KW - Immunohistochemistry

KW - Infant

KW - Laminin

KW - Male

KW - Muscular Dystrophies

KW - Pregnancy

M3 - Journal article

C2 - 9327401

VL - 7

SP - 373

EP - 378

JO - Journal of Neuromuscular Diseases

JF - Journal of Neuromuscular Diseases

SN - 0960-8966

IS - 6-7

ER -

ID: 34325896