TY - JOUR

T1 - Chance of live birth in the first pregnancy after referral among patients with recurrent pregnancy loss is not influenced by their relatives’ reproductive history

AU - Kolte, A. M.

AU - Blom, C.

AU - Shabdar, A.

AU - Christiansen, O. B.

AU - Nielsen, H. S.

PY - 2020

Y1 - 2020

N2 - Purpose: Recurrent pregnancy loss (RPL) is defined as three or more consecutive pregnancy losses and affects 1–3% of couples trying to conceive. Pregnancy loss is more common among RPL patients’ siblings than in the general population. Our objective was to investigate whether first-degree relatives with pregnancy losses influenced the chance of live birth in the first pregnancy after referral among women with RPL. Materials and methods: This is a cohort study of 2138 women with RPL seen at the Danish RPL Unit at Copenhagen University Hospital, Rigshospitalet between January 1st 2000 and December 31st 2017 with follow-up until December 2018. Pregnancies among first-degree relatives were reported by patients at their first consultation. Chance of live birth after referral was compared by logistic regression analysis. Results: Overall, 76% of the referred women achieved a pregnancy after referral and of these, 58% delivered a live born child. Women whose mother had experienced pregnancy loss were referred at a younger age than women with no pregnancy losses among first-degree relatives (mean age 33.6 (SD 4.6) versus 34.3 (SD 4.5), p = 0.002). Pregnancy losses among first-degree relatives did not influence chance of live birth. Conclusions: Our results indicate that pregnancy losses among first-degree family members is not an important risk factor for outcome of the first pregnancy after referral among women with RPL.

AB - Purpose: Recurrent pregnancy loss (RPL) is defined as three or more consecutive pregnancy losses and affects 1–3% of couples trying to conceive. Pregnancy loss is more common among RPL patients’ siblings than in the general population. Our objective was to investigate whether first-degree relatives with pregnancy losses influenced the chance of live birth in the first pregnancy after referral among women with RPL. Materials and methods: This is a cohort study of 2138 women with RPL seen at the Danish RPL Unit at Copenhagen University Hospital, Rigshospitalet between January 1st 2000 and December 31st 2017 with follow-up until December 2018. Pregnancies among first-degree relatives were reported by patients at their first consultation. Chance of live birth after referral was compared by logistic regression analysis. Results: Overall, 76% of the referred women achieved a pregnancy after referral and of these, 58% delivered a live born child. Women whose mother had experienced pregnancy loss were referred at a younger age than women with no pregnancy losses among first-degree relatives (mean age 33.6 (SD 4.6) versus 34.3 (SD 4.5), p = 0.002). Pregnancy losses among first-degree relatives did not influence chance of live birth. Conclusions: Our results indicate that pregnancy losses among first-degree family members is not an important risk factor for outcome of the first pregnancy after referral among women with RPL.

KW - cohort study

KW - family history

KW - Recurrent pregnancy loss

U2 - 10.1080/13625187.2020.1755033

DO - 10.1080/13625187.2020.1755033

M3 - Journal article

C2 - 32436443

AN - SCOPUS:85085483479

VL - 25

SP - 209

EP - 212

JO - The European Journal of Contraception and Reproductive Health Care

JF - The European Journal of Contraception and Reproductive Health Care

SN - 1362-5187

IS - 3

ER -