Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis
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Cerebrospinal fluid (CSF) soluble CD27 (sCD27) is a sensitive biomarker of intrathecal inflammation. Although generally considered a biomarker of T cell activation, CSF sCD27 has been shown to correlate with biomarkers of B cell activity in multiple sclerosis. We analyzed CSF from 40 patients with relapsing-remitting multiple sclerosis (RRMS) and nine symptomatic controls using flow cytometry and multiplex electrochemiluminescence immunoassays. CSF sCD27 levels were increased in RRMS and correlated with IgG index, soluble B cell maturation antigen, cell count, B cell frequency and CD8+ T cell frequency. We provide new data indicating that CSF sCD27 is associated with CD8+ T cells and B cells in RRMS.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 578128 |
| Tidsskrift | Journal of Neuroimmunology |
| Vol/bind | 381 |
| Antal sider | 6 |
| ISSN | 0165-5728 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The study was supported with a grant from Rigshospitalet's Research Fund. SB was supported by grants from the Danish Multiple Sclerosis Society and SC was supported by a Danish Neurological Society Lundbeck Foundation grant. FS holds a professorship at the Faculty of Health Sciences and Medicine, University of Copenhagen sponsored by the Danish Multiple Sclerosis Society.SEM reports non-financial support from Merck for congress participation. SRH, SB, MRM, MBH and SC have nothing to disclose. MRvE has received speaker honoraria from Merck. FS has served on scientific advisory boards for, served as consultant for, received support for congress participation or received speaker honoraria from Alexion, Biogen, Bristol Myers Squibb, Merck, Novartis, Roche and Sanofi Genzyme. His laboratory has received research support from Biogen, Merck, Novartis, Roche and Sanofi Genzyme. JRC has received speaker honoraria from Biogen.
Funding Information:
The study was supported with a grant from Rigshospitalet's Research Fund . SB was supported by grants from the Danish Multiple Sclerosis Society and SC was supported by a Danish Neurological Society Lundbeck Foundation grant. FS holds a professorship at the Faculty of Health Sciences and Medicine, University of Copenhagen sponsored by the Danish Multiple Sclerosis Society .
Publisher Copyright:
© 2023 The Authors
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