Cell biology of mitotic recombination

Forskning

Cell biology of mitotic recombination

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Cell biology of mitotic recombination. / Lisby, Michael; Rothstein, Rodney.

I: Cold Spring Harbor Perspectives in Biology, Bind 7, Nr. 3, a016535, 2015.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lisby, M & Rothstein, R 2015, 'Cell biology of mitotic recombination', Cold Spring Harbor Perspectives in Biology, bind 7, nr. 3, a016535. https://doi.org/10.1101/cshperspect.a016535

APA

Lisby, M., & Rothstein, R. (2015). Cell biology of mitotic recombination. Cold Spring Harbor Perspectives in Biology, 7(3), [a016535]. https://doi.org/10.1101/cshperspect.a016535

Vancouver

Lisby M, Rothstein R. Cell biology of mitotic recombination. Cold Spring Harbor Perspectives in Biology. 2015;7(3). a016535. https://doi.org/10.1101/cshperspect.a016535

Author

Lisby, Michael ; Rothstein, Rodney. / Cell biology of mitotic recombination. I: Cold Spring Harbor Perspectives in Biology. 2015 ; Bind 7, Nr. 3.

Bibtex

@article{0f29d86d2682406da05dfb7113b533f4,

title = "Cell biology of mitotic recombination",

abstract = "Homologous recombination provides high-fidelity DNA repair throughout all domains of life. Live cell fluorescence microscopy offers the opportunity to image individual recombination events in real time providing insight into the in vivo biochemistry of the involved proteins and DNA molecules as well as the cellular organization of the process of homologous recombination. Herein we review the cell biological aspects of mitotic homologous recombination with a focus on Saccharomyces cerevisiae and mammalian cells, but will also draw on findings from other experimental systems. Key topics of this review include the stoichiometry and dynamics of recombination complexes in vivo, the choreography of assembly and disassembly of recombination proteins at sites of DNA damage, the mobilization of damaged DNA during homology search, and the functional compartmentalization of the nucleus with respect to capacity of homologous recombination.",

author = "Michael Lisby and Rodney Rothstein",

year = "2015",

doi = "10.1101/cshperspect.a016535",

language = "English",

volume = "7",

journal = "Cold Spring Harbor Perspectives in Biology",

issn = "1943-0264",

publisher = "Cold Spring Harbor Laboratory Press",

number = "3",

}

RIS

TY - JOUR

T1 - Cell biology of mitotic recombination

AU - Lisby, Michael

AU - Rothstein, Rodney

PY - 2015

Y1 - 2015

N2 - Homologous recombination provides high-fidelity DNA repair throughout all domains of life. Live cell fluorescence microscopy offers the opportunity to image individual recombination events in real time providing insight into the in vivo biochemistry of the involved proteins and DNA molecules as well as the cellular organization of the process of homologous recombination. Herein we review the cell biological aspects of mitotic homologous recombination with a focus on Saccharomyces cerevisiae and mammalian cells, but will also draw on findings from other experimental systems. Key topics of this review include the stoichiometry and dynamics of recombination complexes in vivo, the choreography of assembly and disassembly of recombination proteins at sites of DNA damage, the mobilization of damaged DNA during homology search, and the functional compartmentalization of the nucleus with respect to capacity of homologous recombination.

AB - Homologous recombination provides high-fidelity DNA repair throughout all domains of life. Live cell fluorescence microscopy offers the opportunity to image individual recombination events in real time providing insight into the in vivo biochemistry of the involved proteins and DNA molecules as well as the cellular organization of the process of homologous recombination. Herein we review the cell biological aspects of mitotic homologous recombination with a focus on Saccharomyces cerevisiae and mammalian cells, but will also draw on findings from other experimental systems. Key topics of this review include the stoichiometry and dynamics of recombination complexes in vivo, the choreography of assembly and disassembly of recombination proteins at sites of DNA damage, the mobilization of damaged DNA during homology search, and the functional compartmentalization of the nucleus with respect to capacity of homologous recombination.

U2 - 10.1101/cshperspect.a016535

DO - 10.1101/cshperspect.a016535

M3 - Journal article

C2 - 25731763

VL - 7

JO - Cold Spring Harbor Perspectives in Biology

JF - Cold Spring Harbor Perspectives in Biology

SN - 1943-0264

IS - 3

M1 - a016535

ER -

ID: 136304465