Cause-specific excess mortality in siblings of patients co-infected with HIV and hepatitis C virus.
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Cause-specific excess mortality in siblings of patients co-infected with HIV and hepatitis C virus. / Hansen, Ann-Brit Eg; Lohse, Nicolai; Gerstoft, Jan; Kronborg, Gitte; Laursen, Alex; Pedersen, Court; Sørensen, Henrik Toft; Obel, Niels.
I: P L o S One, Bind 2, Nr. 1, 2007, s. e738.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Cause-specific excess mortality in siblings of patients co-infected with HIV and hepatitis C virus.
AU - Hansen, Ann-Brit Eg
AU - Lohse, Nicolai
AU - Gerstoft, Jan
AU - Kronborg, Gitte
AU - Laursen, Alex
AU - Pedersen, Court
AU - Sørensen, Henrik Toft
AU - Obel, Niels
PY - 2007
Y1 - 2007
N2 - BACKGROUND: Co-infection with hepatitis C in HIV-infected individuals is associated with 3- to 4-fold higher mortality among these patients' siblings, compared with siblings of mono-infected HIV-patients or population controls. This indicates that risk factors shared by family members partially account for the excess mortality of HIV/HCV-co-infected patients. We aimed to explore the causes of death contributing to the excess sibling mortality. METHODOLOGY AND PRINCIPAL FINDINGS: We retrieved causes of death from the Danish National Registry of Deaths and estimated cause-specific excess mortality rates (EMR) for siblings of HIV/HCV-co-infected individuals (n = 436) and siblings of HIV mono-infected individuals (n = 1837) compared with siblings of population controls (n = 281,221). Siblings of HIV/HCV-co-infected individuals had an all-cause EMR of 3.03 (95% CI, 1.56-4.50) per 1,000 person-years, compared with siblings of matched population controls. Substance abuse-related deaths contributed most to the elevated mortality among siblings [EMR = 2.25 (1.09-3.40)] followed by unnatural deaths [EMR = 0.67 (-0.05-1.39)]. No siblings of HIV/HCV co-infected patients had a liver-related diagnosis as underlying cause of death. Siblings of HIV-mono-infected individuals had an all-cause EMR of 0.60 (0.16-1.05) compared with siblings of controls. This modest excess mortality
AB - BACKGROUND: Co-infection with hepatitis C in HIV-infected individuals is associated with 3- to 4-fold higher mortality among these patients' siblings, compared with siblings of mono-infected HIV-patients or population controls. This indicates that risk factors shared by family members partially account for the excess mortality of HIV/HCV-co-infected patients. We aimed to explore the causes of death contributing to the excess sibling mortality. METHODOLOGY AND PRINCIPAL FINDINGS: We retrieved causes of death from the Danish National Registry of Deaths and estimated cause-specific excess mortality rates (EMR) for siblings of HIV/HCV-co-infected individuals (n = 436) and siblings of HIV mono-infected individuals (n = 1837) compared with siblings of population controls (n = 281,221). Siblings of HIV/HCV-co-infected individuals had an all-cause EMR of 3.03 (95% CI, 1.56-4.50) per 1,000 person-years, compared with siblings of matched population controls. Substance abuse-related deaths contributed most to the elevated mortality among siblings [EMR = 2.25 (1.09-3.40)] followed by unnatural deaths [EMR = 0.67 (-0.05-1.39)]. No siblings of HIV/HCV co-infected patients had a liver-related diagnosis as underlying cause of death. Siblings of HIV-mono-infected individuals had an all-cause EMR of 0.60 (0.16-1.05) compared with siblings of controls. This modest excess mortality
U2 - http://dx.doi.org/10.1371/journal.pone.0000738
DO - http://dx.doi.org/10.1371/journal.pone.0000738
M3 - Journal article
VL - 2
SP - e738
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 1
ER -
ID: 34098726