TY - JOUR

T1 - Carrageenans inhibit the in vitro growth of Plasmodium falciparum and cytoadhesion to CD36

AU - Adams, Yvonne

AU - Smith, Simone L.

AU - Schwartz-Albiez, Reinhard

AU - Andrews, Katherine T.

N1 - Funding Information: Acknowledgements We thank Nirmala Pandeya for assistance with the statistical analysis and the Brisbane Red Cross Blood Service for supplying blood and sera. This work was supported by a grant from the Deutsche Forschungsgemeinschaft (DFG) SFB 544 ‘‘Control of Tropical infectious Diseases’’. Yvonne Adams was partially funded by Boehringer Ingelheim Fonds.

PY - 2005/10

Y1 - 2005/10

N2 - Carbohydrates are implicated in many of the invasive and adhesive interactions that occur between Plasmodium falciparum malaria parasites and human host cells, including invasion of sporozoites into hepatocytes, entry of merozoites into new host erythrocytes during asexual blood-stage replication, adhesion of infected erythrocytes to uninfected erythrocytes (rosetting) and to a number of host endothelial receptors including ICAM-1, CD36 and chondroitin-4-sulphate. In addition to increasing our understanding of host-parasite interactions, the investigation of carbohydrates with differing levels and patterns of sulphation as inhibitors may contribute to the development of novel therapeutics targeting malaria. Here we show that three polysaccharides derived from seaweed (carrageenans) with differing sulphation levels and patterns can inhibit the in vitro erythrocytic invasion and growth of both drug sensitive and drug resistant P. falciparum lines and the adhesion of parasitized erythrocytes to the human glycoprotein CD36.

AB - Carbohydrates are implicated in many of the invasive and adhesive interactions that occur between Plasmodium falciparum malaria parasites and human host cells, including invasion of sporozoites into hepatocytes, entry of merozoites into new host erythrocytes during asexual blood-stage replication, adhesion of infected erythrocytes to uninfected erythrocytes (rosetting) and to a number of host endothelial receptors including ICAM-1, CD36 and chondroitin-4-sulphate. In addition to increasing our understanding of host-parasite interactions, the investigation of carbohydrates with differing levels and patterns of sulphation as inhibitors may contribute to the development of novel therapeutics targeting malaria. Here we show that three polysaccharides derived from seaweed (carrageenans) with differing sulphation levels and patterns can inhibit the in vitro erythrocytic invasion and growth of both drug sensitive and drug resistant P. falciparum lines and the adhesion of parasitized erythrocytes to the human glycoprotein CD36.

UR - http://www.scopus.com/inward/record.url?scp=27144498644&partnerID=8YFLogxK

U2 - 10.1007/s00436-005-1426-3

DO - 10.1007/s00436-005-1426-3

M3 - Journal article

C2 - 16012863

AN - SCOPUS:27144498644

VL - 97

SP - 290

EP - 294

JO - Parasitology Research

JF - Parasitology Research

SN - 0932-0113

IS - 4

ER -